Pulmonary malignant granular cell tumor
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Case report
Pulmonary malignant granular cell tumor Ming Jiang1, Timothy Anderson2, Chukwumere Nwogu2 and Dongfeng Tan*1 Address: 1Department of Pathology Roswell Park Cancer Institute, State University of New York, Buffalo, New York 14263, USA and 2Department of Thoracic Surgery, Roswell Park Cancer Institute, State University of New York, Buffalo, New York 14263, USA Email: Ming Jiang - [email protected]; Timothy Anderson - [email protected]; Chukwumere Nwogu - [email protected]; Dongfeng Tan* - [email protected] * Corresponding author
Published: 21 October 2003 World Journal of Surgical Oncology 2003, 1:22
Received: 20 August 2003 Accepted: 21 October 2003
This article is available from: http://www.wjso.com/content/1/1/22 © 2003 Jiang et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
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Abstract Background: Malignant granular cell tumor (MGCT) is a rare disease entity. Forty-one welldocumented MGCTs have been reported in the world literature. Case Report: This report describes a patient who presented with a MGCT of the lung and reviews the preoperative evaluation, pathologic features and differential diagnosis of the disease. This case represents the first report of resected primary pulmonary MGCT. Conclusions: Diagnosis of MGCT is based on histology of the primary tumor, immunohistochemistry, and exclusion of tumors that may mimic granular cell tumor.
Introduction Granular cell tumors (GCT) are uncommon, usually benign neoplasms, most frequently originating from tongue, skin, and breast [1,2]. Since the first case of GCT from the trachea and bronchus was described in the late 1930s, less than 80 cases have been reported as originating from in the tracheobronchial tree, all of which were benign. One report suggested a MGCT co-existing with small cell lung cancer; however, no histology proof was available since the tumor was not resected [3]. In this report, we describe a patient who presented with a MGCT of the lung and discuss the preoperative considerations and evaluation, differential diagnosis, and the pathologic features of this rare malignancy.
Case Report A 32-year-old Caucasian woman who was in her usual state of health until approximately 2 months ago was admitted for her new onset of chest pain and shortness of
breath. She had a longstanding history of smoking since the age of 9, roughly 2–3 packs per day. Physical examination was within normal limits; no evidence of peripheral adenopathy or cutaneous nodules was noted. A chest xray and CT scan revealed a solitary pulmonary mass (Fig. 1, 2). The mass was round and smooth, 2.8 cm in diameter, and centrally located within the left lower lobe. Additional work-up including abdominal and pelvic CT scans revealed no extra-pulmonary lesions. Because of her significant smoking hi
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