Purinergic Regulation of Respiratory Diseases

We proudly present the first book to integrate all aspects of purinergic signaling in the respiratory system. The first chapters introduce basic notions of purinergic pharmacology and metabolism, which allows readers from all scientific backgrounds to ful

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SUBCELLULAR BIOCHEMISTRY SERIES EDITOR J. ROBIN HARRIS, University of Mainz, Mainz, Germany

ASSISTANT EDITORS B.B. BISWAS, University of Calcutta, Calcutta, India P. QUINN, King’s College London, London, UK Recent Volumes in this Series Volume 41

Chromatic and Disease Edited by Tapas K. Kundu and Dipak Dasgupta

Volume 42

Inflammation in the Pathogenesis of Chronic Disease Edited by Randall E. Harris

Volume 43

Subcellular Proteomics Edited by Eric Bertrand and Michel Faupel

Volume 44

Peroxiredoxin Systems Edited by Leopold Folhe´ and J. Robin Harris

Volume 45

Calcium Signalling and Disease Edited by Ernesto Carafoli and Marisa Brini

Volume 46

Creatine and Creatine Kinase in Health and Disease Edited by Gajja S. Salomons and Markus Wyss

Volume 47

Molecular Mechanisms of Parasite Invasion Edited by Barbara A. Burleigh and Dominique Soldati-Favre

Volume 48

The Cronin Family of Proteins Edited by Christoph S. Clemen and Ludwig Eichinger

Volume 49

Lipids in Health and Disease Edited by Peter J. Quinn and Xiaoyuan Wang

Volume 50

Genome Stability and Human Diseases Edited by Heinz-Peter Nasheuer

Volume 51

Choloesterol Binding and Cholesterol Transport Proteins Edited by Robin J. Harris

Volume 52

A Handbook of Transcription Factors Edited by Tim Hughes

Volume 53

Endotoxins: Stricture, Function and Recognition Edited by Xiaoyuan Wang and Peter J. Quinn

Volume 54

Conjugation and Deconjugation of Ubiquitin Family Modifiers Edited by Marcus Groettrup

Maryse Picher Editor-in-Chief

Richard C. Boucher Editor

Purinergic Regulation of Respiratory Diseases

Editor-in-Chief Maryse Picher Cystic Fibrosis Pulmonary Research and Treatment Center University of North Carolina 7011 Thurston-Bowles building Chapel Hill, NC 27599 USA [email protected]

Editor Richard C. Boucher Cystic Fibrosis Pulmonary Research and Treatment Center University of North Carolina 7011 Thurston-Bowles building Chapel Hill, NC 27599 USA [email protected]

ISSN 0306-0225 ISBN 978-94-007-1216-4 e-ISBN 978-94-007-1217-1 DOI 10.1007/978-94-007-1217-1 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011928079 # Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)

INTERNATIONAL ADVISORY EDITORIAL BOARD R. Bittman, Queens College, City University of New York, New York, USA D. Dasgupt, Saha Institute of Nuclear Physics, Calcutta, India A. Holzenburg, Texas A&M University, Texas, USA S. Rottem, The Hebrew University, Jerusalem, Israel M. Wyss, DSM Nutritional Products Ltd., Basel, Switzerland

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