Reprogramming of Tumor Microenvironment in Therapy
The tumor microenvironment is a pathological niche in which progression of cancer occurs. The microenvironment is created, among others, by cancer-specific fibroblasts (CAFs), endothelial cells of tumor blood vessels, and immune cells that inhibit the ant
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Cancer Immunology
Nima Rezaei Editor
Cancer Immunology Bench to Bedside Immunotherapy of Cancers Second Edition
Editor Nima Rezaei Research Center for Immunodeficiencies Children’s Medical Center Tehran University of Medical Sciences Tehran Iran Department of Immunology School of Medicine Tehran University of Medical Sciences Tehran Iran Network of Immunity in Infection Malignancy and Autoimmunity (NIIMA)
Universal Scientific Education and Research Network (USERN) Tehran Iran
ISBN 978-3-030-50286-7 ISBN 978-3-030-50287-4 (eBook) https://doi.org/10.1007/978-3-030-50287-4 © Springer Nature Switzerland AG 2015, 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
This book would not have been possible without the continuous encouragement by my parents and my wife, Maryam. I wish to dedicate it to my daughters, Ariana and Arnika, with the hope that progress in diagnosis and treatment of these diseases may result in improved survival and quality of life for the next generations, and at the same time that international collaboration in research will happen without barriers. Whatever I have learnt comes from my mentors. This book is therefore dedicated also to all of them, but most importantly to the patients and their families whose continuous support has guided me during the years.
Preface
The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses
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