The Smoothened Receptor in Cancer and Regenerative Medicine
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuitio
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Martial Ruat Editor
The Smoothened Receptor in Cancer and Regenerative Medicine
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Topics in Medicinal Chemistry
Editorial Board: P. R. Bernstein, Rose Valley, USA A. Buschauer, Regensburg, Germany G. I. Georg, Minneapolis, USA J. A. Lowe, Stonington, USA U. Stilz, Malov, Denmark Prof. Dr. C. T. Supuran, Sesto Fiorentino (Firenze), Italy A. K. Saxena, Lucknow, India
Aims and Scope Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the new topic-related series Topics in Medicinal Chemistry will cover all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. In references Topics in Medicinal Chemistry is abbreviated Top Med Chem and is cited as a journal.
More information about this series at http://www.springer.com/series/7355
Martial Ruat Editor
The Smoothened Receptor in Cancer and Regenerative Medicine
With contributions by R. Andriantsitohaina M. Daynac H. Faure L. Hoch J. Jiang F. Manetti M.C. Martı´nez I. Mus-Veteau E. Petricci N.A. Riobo D. Rognan M. Ruat Q. Shi R. Soleti M. Taddei
Editor Martial Ruat Institute of Neurosciences Paris-Saclay (Neuro-PSI) National Centre for Scientific Research Gif-Yvette, France
ISSN 1862-2461 ISSN 1862-247X (electronic) Topics in Medicinal Chemistry ISBN 978-3-319-19754-8 ISBN 978-3-319-19755-5 (eBook) DOI 10.1007/978-3-319-19755-5 Library of Congress Control Number: 2015943691 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor
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