Quality of life and the negative impact of comorbidities in long-term colorectal cancer survivors: a population-based co
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Quality of life and the negative impact of comorbidities in long-term colorectal cancer survivors: a population-based comparison Amy Pate 1 & Jan Lowery 2 & Kristin Kilbourn 3 & Patrick J. Blatchford 4 & Monica McNulty 4 & Betsy Risendal 5,6 Received: 6 January 2020 / Accepted: 5 March 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose Colorectal cancer (CRC) is the third most common cancer in the USA. The objective of this study was to compare quality of life (QoL) across long-term colorectal cancer survivors and unaffected matched controls while adjusting for comorbidities. Methods The National Cancer Institute (NCI)-funded Colon Cancer Family Registry (CCFR) was used to randomly select and recruit CRC survivors (≥ 5 years from diagnosis) and matched controls for a cross-sectional survey. Nine geographically diverse sites in the USA from the CCFR participated in the study. Telephone interviews were conducted using computer-assisted methods to assess QoL. Results A total of 403 cases and 401 controls were included in the final sample. Unadjusted comparison revealed no significant difference between CRC survivors and controls with respect to measures of fatigue, social, emotional, functional, and physical well-being. Multivariate logistic regression revealed that case status had a significant negative influence on colorectal cancerspecific QoL measures. Higher comorbidity indices had a significant negative influence on overall QoL regardless of case status. Conclusions Quality of life among long-term CRC survivors is similar to control subjects, with the exception of worse CRCspecific QoL measures. Higher comorbidity indices were independently associated with poor QoL for both cases and controls. Implications for Cancer Survivors Survivors and healthcare providers should be aware that long-term QoL is comparable to the general population; however, there is potential that digestive tract-specific issues may persist. Keywords Long-term survivorship . Colorectal cancer . Colon cancer . Quality of life . Global quality of life
Introduction Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the USA [1, 2]. Estimates suggest that more
* Betsy Risendal [email protected] 1
Preventive Medicine Residency, University of Colorado–Anschutz Medical Campus, Aurora, CO, USA
2
Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA
3
Department of Psychology, University of Colorado Denver, Denver, CO, USA
4
Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA
5
Department of Community and Behavioral Health, Colorado School of Public Health, 13001 E. 17th Place, Bldg 500, MS F538, Aurora, CO 80045, USA
6
University of Colorado Comprehensive Cancer Center, Aurora, CO, USA
than 140,000 adults are diagnosed annually [2]. Mortality has sharply declined over the past three decades due to improvements in treatment, changing risk factor patterns, and early detection via screening, and contin
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