Quality of Life in Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy: Chinese Perspectives
Ankylosing spondylitis and undifferentiated spondyloarthritis are the most commonly recognized clinical subtypes of spondyloarthropathies. The major morbidities of both diseases are functional disability and decrease in the quality of life. The most widel
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Springer Science+Business Media LLC 2010 (USA)
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Quality of Life in Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy
Abstract: Ankylosing spondylitis and undifferentiated spondyloarthritis are the most commonly recognized clinical subtypes of spondyloarthropathies. The major morbidities of both diseases are functional disability and decrease in the quality of life. The most widely used sets of criteria for diagnosing spondyloarthritis are the European Spondyloarthropathy Study Group criteria and > Amor criteria. Validation studies of both sets in Chinese patients with spondyloarthritis showed a high sensitivity and specificity. However, a new diagnostic algorithm needs to be developed to identify patients at an early stage of disease. Currently different kinds of instruments have been tested to evaluate the quality of life in patients with ankylosing spondylitis from different populations. A specific ankylosing spondylitis quality of life questionnaire has recently been developed recently and validated in a Chinese population. When applying it in a clinical trial regarding the management of ankylosing spondylitis patients with biologic agents, the results suggest that ankylosing spondylitis quality of life questionnaire, activity of the disease (the Bath Ankylosing Spondylitis Activity Index) and metrology (the Bath Ankylosing Spondylitis Metrology Index) are the important parameters for assessing physical function in ankylosing spondylitis. In addition, following therapy the improvement identified using the ankylosing spondylitis quality of life questionnaire significantly correlated with findings identified with other questionnaires of disease activity and function such as the Bath Ankylosing Spondylitis Activity Index and the Bath Ankylosing Spondylitis Functional Index. However, the exact role of biologic agents in management of ankylosing spondylitis or other spondyloarthritis in Chinese populations needs further evaluation. List of Abbreviations: AS, ankylosing spondylitis; ASQOL, ankylosing spondylitis quality of life questionnaire; BASDAI, the bath ankylosing spondylitis activity index; BASFI, the bath ankylosing spondylitis functional index; BAS-G, the bath ankylosing spondylitis global assessment; BASMI, the bath ankylosing spondylitis metrology index; COPCORD, community orientated program for the control of rheumatic diseases; CRP, C-reactive protein; DFI, Dougados functional index; ESR, erythrocyte sedimentation rate; ESSG, European spondyloarthropathy study group; HLA-B27, human leucocyte antigen B27; Hs-CRP, high sensitivity C-reactive protein; MRI, magnetic resonance imaging; NSAIDs, nonsteroid anti-inflammatory drugs; QOL, quality of life; SF-36, short form-36; SpA, spondyloarthritis; USpA, undifferentiated spondyloarthritis; VAS, visual assessment scale
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Introduction
The Spondyloarthropathies (SpA) are a family of arthritis conditions that share common clinical features including: degree of enthesitis, axial skeletal involvement, and contribution of the MHC class I
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