Quantitative assessment of mineralization in distraction osteogenesis
- PDF / 255,622 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 58 Downloads / 236 Views
SCIENTIFIC ARTICLE
Quantitative assessment of mineralization in distraction osteogenesis Sunit Hazra & Hae-Ryong Song & Sandeep Biswal & Suk-Ha Lee & Seok Hyun Lee & Ki-Mo Jang & Hitesh N. Modi
Received: 13 January 2008 / Revised: 19 February 2008 / Accepted: 13 March 2008 / Published online: 24 April 2008 # ISS 2008
Abstract Objectives The most important decision in distraction osteogenesis is the timing of fixator removal. Various methods have been tried, such as radiographic appearance of callus and bone mineral density (BMD) assessment, but none has acquired gold standard status. The purpose of this study was to develop another objective method of assessment of callus stiffness to help clinicians in taking the most important decision of when to remove the fixator. Materials and methods We made a retrospective study of 70 patients to compare the BMD ratio and pixel value ratio. These ratios were calculated at the time of fixator removal, and Pearson’s coefficient of correlation was used to show The authors certify that they have no commercial associations that might pose a conflict of interest in connection with the submitted article. No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. S. Hazra : S. Biswal : K.-M. Jang : H. N. Modi Department of Orthopedic Surgery, Korea University, Guro Hospital, Seoul, Korea H.-R. Song (*) Department of Orthopedic Surgery, Rare Diseases Institute, Korea University, Guro Hospital, 80, Guro-Dong, Guro-Gu, Seoul 152-703, Korea e-mail: [email protected] S.-H. Lee Department of Orthopedics, Konkuk University Hospital, Seoul, Korea S. H. Lee Department of Orthopedic Surgery, Dongguk University International Hospital, Ilsan, Korea
the comparability. Inter- and intra-observer variability of the new method was also tested. Results Good correlation was found between BMD ratio and pixel value ratio, with a Pearson’s coefficient of correlation of 0.79. The interobserver variability was also low, with high intra-observer reproducibility, suggesting that this test was simple to perform. Conclusion Pixel value ratio is a good method for assessing callus stiffness, and it can be used to judge the timing of fixator removal. Keywords Distraction osteogenesis . BMD . Callus stiffness . Pixel . Lengthening . Ilizarov
Introduction The most critical decision in the process of distraction osteogenesis (DO) is when to remove the external fixator. Standard radiography in two planes, together with the surgeon’s clinical judgment, remains the main tool in clinical practice [1, 2]. Traditional radiographic techniques only allow qualitative assessment of new bone formation, thus providing limited guidance in deciding when to discontinue use of the fixator [3]. Quantitative methods include quantitative computer tomography [4], quantitative technetium scintigraphy [5] and dual-energy X-ray absorptiometry (DEXA) [6–8]. These methods measure callus mineralization, which has been found to correlate well with
Data Loading...
