Quantitative Pectoralis Muscle Area is Associated with the Development of Lung Cancer in a Large Lung Cancer Screening C
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LUNG CANCER
Quantitative Pectoralis Muscle Area is Associated with the Development of Lung Cancer in a Large Lung Cancer Screening Cohort Lee Gazourian1 · Chantal S. Durgana2 · Devon Huntley3 · Giulia S. Rizzo4 · William B. Thedinger3 · Shawn M. Regis5 · Lori Lyn Price6,7 · Elizabeth J. Pagura1 · Carla Lamb1 · Kimberly Rieger‑Christ8 · Carey C. Thomson9,10 · Cristina F. Stefanescu11 · Ava Sanayei3 · William P. Long3 · Andrea B. McKee5 · George R. Washko12,13 · Raul San José Estépar13,14 · Christoph Wald15 · Timothy N. Liesching1 · Brady J. McKee15 Received: 23 May 2020 / Accepted: 20 August 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Studies have demonstrated an inverse relationship between body mass index (BMI) and the risk of developing lung cancer. We conducted a retrospective cohort study evaluating baseline quantitative computed tomography (CT) measurements of body composition, specifically muscle and fat area in a large CT lung screening cohort (CTLS). We hypothesized that quantitative measurements of baseline body composition may aid in risk stratification for lung cancer. Methods Patients who underwent baseline CTLS between January 1st, 2012 and September 30th, 2014 and who had an innetwork primary care physician were included. All patients met NCCN Guidelines eligibility criteria for CTLS. Quantitative measurements of pectoralis muscle area (PMA) and subcutaneous fat area (SFA) were performed on a single axial slice of the CT above the aortic arch with the Chest Imaging Platform Workstation software. Cox multivariable proportional hazards model for cancer was adjusted for variables with a univariate p
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