Quinine
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Acquired auditory neuropathy spectrum disorder: case report A 13-year-old girl developed acquired auditory neuropathy spectrum disorder (ANSD) during treatment with quinine for malaria. The girl was diagnosed with severe malaria resulting in loss of consciousness. She started receiving treatment with IV quinine [dosage not stated]. After recovery of malaria, her family noted a sudden onset of hearing difficulties. Prior to the malaria infection, she was reportedly healthy with no family history of peripheral neuropathy or hearing loss. Audiological assessment showed no abnormalities on tympanometry or otoscopy. On diagnostic transient-evoked otoacoustic emissions (TEOAE) testing, a clear responses (bilaterally) were noted. Pure tone audiometry revealed a moderate reverse-slope sensorineural bilateral hearing loss. Auditory brainstem response (ABR)test using 70 dBnHL click air conduction revealed no discernible waveforms (bilaterally). Ipsilateral acoustic reflex thresholds were absent in both the ears. Her audiological results were indicative of ANSD. There were no reports of any trauma or illness during eights months between audiological assessment and the onset of malaria. During this period, she received no medications. The ANSD was thought to related to malaria and/or quinine treatment [time to reaction onset and outcome not stated]. Brough H. Acquired auditory neuropathy spectrum disorder after malaria treated with quinine. Tropical Doctor 50: 246-248, No. 3, Jul 2020. Available from: URL: http:// 803499460 doi.org/10.1177/0049475520917236
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Reactions 5 Sep 2020 No. 1820
