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RAD50
Definition
Definition
50 -rapid amplification of cDNA ends (50 -RACE) allows the amplification of the 50 end of a cDNA where there is incomplete knowledge of the mRNA of interest. ! PCR primers are designed for the known sequence within the mRNA and for a homopolymer tail that has been added to the 30 end of the first strand of cDNA. The amplified fragment, obtained by nested PCR, contains the 50 remainder of the cDNA that is followed by the known cDNA sequence.
Rad50 is a protein forming a multi-function complex with ! Mre11 and Nbs1 [! Nijmegen breakage syndrome], and is involved in the processing of DNA damage for DNA maintenance including ! repair of DNA and recombination.
Rac-GAP Definition Rac-GAP is a GTPase-activating protein for Rac, which is a small GTP-binding protein and member of the family of Ras-homology proteins (! Rho family proteins).
RACKS Definition Receptors for activated C kinase.
RAD51 Definition Rad51 is a protein found in all eukaryotic organisms from yeast to man, with a central role in homologous recombination. It has homology to the bacterial ! RecA protein, and similarly catalyses pairing and strand exchange between a damaged DNA molecule and an undamaged homologous molecule (! homologous recombination repair).
RAD52 Definition Rad52 is a recombination protein facilitating ! Rad51-mediated homologous pairing of DNA.
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RAD54
RAD54
Rapamycin
Definition
Definition
Rad54 is a member of protein family suggested to have DNA helicase activity, unwinding DNA to promote recombination.
Rapamycin is a bacterial macrolide with antibiotic and immunosuppressive activity and structural similarity to FK506. In a complex with FK506 binding protein (FKBP), rapamycin inhibits ! TOR (target of rapamycin). Rapamycin treatment of cells leads to dephosphorylation and inactivation of p70S6 kinase and also to dephosphorylation of 4E-BP1 (eukaryotic initiation factor 4E binding protein 1), thereby promoting its binding to and inactivation of eIF4E (eukaryotic initiation factor 4E), leading to a cell cycle arrest in G1 phase.
Radiation Therapy Definition Radiation therapy, also known as radiotherapy, is a kind of therapy that uses radiation energy that comes from radioactive materials to fight neoplastic disease. It is typically performed with an external beam origin.
RAS Angel Pellicer
Radioresistant DNA Synthesis Definition Radioresistant DNA synthesis (RDS) is the continued replication of a cell's DNA despite an ionising radiation challenge. The majority of normal cells react to ionising radiation by halting replication of their (damaged) DNA.
New York University School of Medicine, New York, USA [email protected]
Definition The word Ras comes from a contraction of Rat sarcoma, the tumor where the first gene of the family was identified, as part of the genome of a ! retrovirus isolated from a carcinogenesis protocol (! oncogenes).
Characteristics
RAF-1 Definition Raf-1 is a dominant ! oncogene coding for the serine/threonine kinase p74raf-1 that bears homology to ! protein ki
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