Radionuclide therapy using nanoparticle of 131 I-Lactosome in combination with percutaneous ethanol injection therapy
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RESEARCH PAPER
Radionuclide therapy using nanoparticle of 131I-Lactosome in combination with percutaneous ethanol injection therapy Eri Hara • Akira Makino • Kensuke Kurihara • Motoki Ueda • Isao Hara • Takashi Kawabe • Fumihiko Yamamoto Eiichi Ozeki • Kaori Togashi • Shunsaku Kimura
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Received: 23 August 2013 / Accepted: 13 November 2013 / Published online: 24 November 2013 Ó Springer Science+Business Media Dordrecht 2013
Abstract We present here a radionuclide therapy using nanoparticle of 131I-labeled Lactosome (131I-Lactosome) is effective as a tumor therapy when combined with the local therapy of the percutaneous ethanol injection therapy (PEIT). A mixture of 131 I-labeled poly(L-lactic acid)30 and amphiphilic block polymer of poly(sarcosine)64-block-poly(L-lactic acid)30 was dispersed in saline to generate polymeric micelles of 131I-Lactosome (the diameter of 46 nm with PDI of 0.057). Mice were transplanted with murine mammary cancer (4T1) cells, and a relatively small amount of ethanol was injected percutaneously to the tumor region, followed by Electronic supplementary material The online version of this article (doi:10.1007/s11051-013-2131-2) contains supplementary material, which is available to authorized users. E. Hara Department of Experimental Therapeutics, Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto 606-8507, Japan A. Makino Division of Molecular Imaging, Biomedical Imaging Research Center, University of Fukui, Fukui 910-1193, Japan
intravenous administration of 131I-Lactosome (2.0 9 102 MBq/kg). At 16 days after the 131I-Lactosome dosage with PEIT, the relative tumor volume (RTV) was suppressed as low as 5.32 ± 1.06, while the RTV values became significant to be 15.9 ± 5.0 with PEIT alone and 17.4 ± 3.9 with 131I-Lactosome alone. Indeed, 131I-accumulation in the transplanted tumor region at 48 h after 131I-Lactosome dosage became three times higher with PEIT than that without PEIT. The nanoparticle-based radionuclide therapy in combination with PEIT was, therefore, effective in suppression of tumor proliferation. Keywords Nanoparticle Lactosome Anti-tumor activity Radiation therapy Percutaneous ethanol injection therapy Nanomedicine F. Yamamoto Department of Radiopharmacy, Tohoku Pharmaceutical University, Sendai 981-8558, Japan S. Kimura (&) Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan e-mail: [email protected]
K. Kurihara M. Ueda K. Togashi Clinical Division of Diagnostic Radiology, Kyoto University Hospital, Kyoto 606-8507, Japan I. Hara T. Kawabe E. Ozeki Technology Research Laboratory, Shimadzu Corporation, Kyoto 619-0237, Japan
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Introduction Local tumor therapies like radiofrequency ablation (RFA) and percutaneous ethanol injection therapy (PEIT) have been developed for patients who could not get invasive surgery for their age and tumor region (Ansari and Andersson 2012; Levy and Kowdley 2001). RFA currently has become one of the tr
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