Randomized Controlled Clinical Trial of Sclerotherapy Alone Versus Sclerotherapy Plus Saphenofemoral Junction Ligation i

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ORIGINAL ARTICLE

Randomized Controlled Clinical Trial of Sclerotherapy Alone Versus Sclerotherapy Plus Saphenofemoral Junction Ligation in Great Saphenous Varicose Vein Vikas Gupta 1

&

Rajdeep Singh 1 & P. N. Agarwal 1 & Anurag Mishra 1 & Anjali Prakash 2 & Tirlok Chand 1

Received: 7 January 2020 / Accepted: 18 September 2020 # The Author(s) 2020

Abstract Varicose veins are a common presentation, and its treatment has been a challenge for surgeons. Many studies have evaluated the efficacy of foam sclerotherapy with a high failure rate. One of the postulated reasons is inadequate obliteration of saphenofemoral junction with foam sclerotherapy. To test this hypothesis we compared whether there is a decrease in reflux with saphenofemoral junction ligation, along with foam sclerotherapy. Forty-eight patients (50 legs) with primary varicosities of the Great saphenous vein system were randomized into two groups: saphenofemoral junction ligation with foam sclerotherapy (SFJL + FS) and foam sclerotherapy alone (FS), and followed up at 2 months. There was complete disappearance of varicose veins in great saphenous vein territory in 96% of patients in SFJL + FS group, and 88% of patients in FS group. Veins ≥ 8 mm in diameter were incompletely occluded with sclerotherapy. Patient satisfaction score was comparable in both the groups. The addition of saphenofemoral junction ligation to foam sclerotherapy offers no additional patient benefit, particularly with regard to disappearance of varicose veins, relief of symptoms, recurrence, and morbidity. However, in large diameter veins (≥ 8 mm), saphenofemoral junction ligation with foam sclerotherapy gives better results. Keywords Varicose veins . Foam sclerotherapy . Saphenofemoral junction ligation

Introduction Varicose veins are dilated subcutaneous veins which are ≥ 3 mm in diameter while standing. Varicose veins and venous insufficiency of the lower extremity are among the most common disease entities affecting the adult population with an estimated 25% of women and 15% of men (older than 15 years) being affected [1]. Varicosities associated with symptoms of venous disease (leg pain, edema, night cramps, skin changes, etc.) have been a topic of interest due to decreased quality of life

* Vikas Gupta [email protected] 1

Department of General Surgery, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India

2

Department of Radiodiagnosis, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India

(QOL) and economic burden to society. The Venous Insufficiency Epidemiological and Economical Study (VEINES) showed that 65.2% of subjects with varicose veins had concomitant venous disease and that physical and mental quality of life scores decreased as the severity of venous disease increased [2]. For the most severe cases of venous disease, quality of life scores were worse than individuals suffering from chronic lung disease, back pain, and arthritis [2]. The treatment of varicose veins has been a challenge for surgeons, and research has been on to f