Rapid analysis of lithium in serum samples by thermal ionization ion mobility spectrometry
- PDF / 1,521,932 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 7 Downloads / 251 Views
ORIGINAL RESEARCH
Rapid analysis of lithium in serum samples by thermal ionization ion mobility spectrometry Razieh Parchami 1 & Mahmoud Tabrizchi 1,2
&
Hassan Shahraki 1 & Ali Moaddeli 3
Received: 11 April 2020 / Revised: 3 June 2020 / Accepted: 8 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract A new application of thermal ionization ion mobility spectrometry (TI–IMS) was presented for the fast determination of lithium ion (Li+) in serum samples. This research aims to provide a selective approach to facilitate lithium monitoring for bipolar patients. The method is based on an initial step of quick–burning the organic content of the diluted serum sample on a hot filament followed by the emission of alkali ions remained in the ash. The drift tube temperature was optimized to maximize the separation of signal from the other existing alkali ions, sodium (Na+) and potassium (K+). The filament temperature and the dilution ratio were also optimized for best observation of the Li+ signal among the excess amount of Na+ and K+. The best peak resolution was obtained at 1:200 dilution ratio and drift tube temperature of 160 °C. TI–IMS demonstrated high sensitivity in both diluted standard and serum sample solution (0.21 μM for LOD and 1.50 μM for LOQ). The Relative standard deviation of the lithium determination was obtained to be 5.4%. Method validation was conducted by comparing the results with those obtained through the inductively coupled plasma optical emission spectrometry (ICP–OES) method. A good agreement between the results was observed indicating that the TI–IMS method can be potentially applied to routine analysis of biological samples. Rapidity, ease of operation and low–cost analysis are superior features of the proposed technique over the traditional approaches. Keywords Lithium monitoring . Thermal ionization . Ion mobility spectrometry . Biological samples
Introduction Lithium is universally accepted as the first–choice mood–stabilizer for treatment of mania and bipolar disorder [1]. During the course of the treatment, the concentration level of lithium ion in blood must be kept in the range of 0.6–1.2 mM. A serum level below this range is not effective, while greater than 1.5 mM is associated with potential toxicity [2]. High concentration of lithium in blood or serum causes irrevocable damage in the nervous system and kidneys and even lethal toxicity to the patients [3].
* Mahmoud Tabrizchi [email protected] 1
Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran
2
CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, People’s Republic of China
3
Legal Medicine Research Center, Legal Medicine Organization, Tehran 1114795113, Iran
Due to such narrow therapeutic window, lithium monitoring has critical and vital importance [4, 5]. Currently, several analytical methods have been described for lithium monitoring in different biological samples,
Data Loading...
