Real-world clinical features of and antidepressant prescribing patterns for outpatients with bipolar disorder
- PDF / 577,384 Bytes
- 11 Pages / 595.276 x 790.866 pts Page_size
- 92 Downloads / 168 Views
RESEARCH ARTICLE
Open Access
Real-world clinical features of and antidepressant prescribing patterns for outpatients with bipolar disorder Keita Tokumitsu1, Norio Yasui-Furukori1,2* , Naoto Adachi3, Yukihisa Kubota3, Yoichiro Watanabe3, Kazuhira Miki3, Takaharu Azekawa3, Koji Edagawa3, Eiichi Katsumoto3, Seiji Hongo3, Eiichiro Goto3, Hitoshi Ueda3, Masaki Kato2,4, Reiji Yoshimura2,5, Atsuo Nakagawa2,6, Toshiaki Kikuchi2,6, Takashi Tsuboi2,7, Kazutaka Shimoda1 and Koichiro Watanabe2,7
Abstract Background: Several evidence-based practice guidelines have been developed to better treat bipolar disorder. However, the articles cited in these guidelines were not sufficiently based on real-world clinical practice. Methods: The MUlticenter treatment SUrvey on BIpolar disorder in Japanese psychiatric clinics (MUSUBI) is a study conducted to accumulate evidence on the real-world practical treatment of bipolar disorder. Psychiatrists were asked to complete a questionnaire about patients with bipolar disorder by performing a retrospective medical record survey. The questionnaire included patient characteristics (age, gender, height, weight, academic background, and occupational status), comorbidities, mental status, treatment period, Global Assessment of Functioning (GAF) score, and details of pharmacological treatment. Results: Data on 2705 patients were included in this study. The proportion of patients receiving antidepressant prescriptions was 40.9%. The most commonly used antidepressant was duloxetine, and the most frequently used antidepressant class was selective serotonin reuptake inhibitors (SSRIs). Binomial logistic regression analysis and bivariate analysis revealed that the usage of antidepressants was correlated with low prescription rates for mood stabilizers, high prescription rates for anxiolytics and hypnotics, and low GAF scores. In addition, patients in a depressive state had a significantly higher rate of antidepressant prescriptions than patients with other mental states. Conclusions: Approximately 40% of patients in Japan with a diagnosis of bipolar disorder have received antidepressants. Antidepressants were most often prescribed in combination with mood stabilizers, antipsychotics or both. Patients who were prescribed antidepressants received fewer mood stabilizers, more anxiolytics, and more hypnotics than those who did not receive antidepressant prescriptions. Keywords: Bipolar disorder, Antidepressant, Nationwide study, Real world
* Correspondence: [email protected] 1 Department of Psychiatry, Dokkyo Medical University, School of Medicine, Mibu, Shimotsuga, Tochigi 321-0293, Japan 2 The Japanese Society of Clinical Neuropsychopharmacology, Tokyo, Japan Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original
Data Loading...
