Real-World Outcomes of Pazopanib Treatment in Korean Patients with Advanced Soft Tissue Sarcoma: A Multicenter Retrospec
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ORIGINAL RESEARCH ARTICLE
Real‑World Outcomes of Pazopanib Treatment in Korean Patients with Advanced Soft Tissue Sarcoma: A Multicenter Retrospective Cohort Study Chung Ryul Oh1 · Jung Yong Hong2 · Jee Hung Kim3,5 · Ji Sung Lee4 · Hyo Song Kim5 · Tae Won Kim1 · Jin‑Hee Ahn1 · Jeong Eun Kim1
© Springer Nature Switzerland AG 2020
Abstract Background Pazopanib is the only tyrosine kinase inhibitor approved for the treatment of patients with advanced soft tissue sarcoma (STS) who have received prior chemotherapy, but there have been limited real-world data on pazopanib for the treatment of advanced STS. Objective We aimed to evaluate clinical outcomes of pazopanib in patients with multiple histologic STS types in real-world settings. Patients and Methods We retrospectively analyzed clinical data of Korean patients with advanced STS treated with pazopanib between 2008 and 2019. Outcomes of interest included treatment response, survival according to histologic subtypes, and adverse events. Results The analysis included 347 STS patients. The disease control rate for all pazopanib-treated patients was 54.8% (95% confidence interval (CI) 49.5–60.0); 54 patients (15.6%) achieved a partial response and 136 (39.2%) had stable disease. Patients with alveolar soft-part sarcoma (ASPS; 90%), solitary fibrous tumor (SFT; 88.2%), synovial sarcoma (66.7%), leiomyosarcoma (61.1%), and undifferentiated pleomorphic sarcoma (59.6%) showed higher disease control rates than those with other STS subtypes. Overall, median progression-free survival (PFS) and overall survival (OS) were 5.3 months (95% CI 4.5–6.0) and 12 months (95% CI 10–14), respectively. Noticeable survival outcomes occurred in patients with ASPS and SFT, with a median PFS of 24.5 (95% CI 2.5–30.0) and 13.0 (95% CI 3.0–21.3) months, respectively. The median OS of patients with ASPS and SFT was 48 (95% CI 17–52) and 32 (95% CI 19–66) months, respectively. Adverse drug reactions occurred in 170 patients (49.0%) but were not life-threatening. Conclusions This real-world data analysis showed acceptable efficacy and tolerability of pazopanib in patients pretreated with cytotoxic chemotherapy for advanced STS, with favorable treatment outcomes for ASPS and SFT.
Key Points Pazopanib showed acceptable efficacy for advanced soft tissue sarcoma (STS) in a real-world setting. Chung Ryul Oh, Jung Yong Hong, and Jee Hung Kim contributed equally to this study. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11523-020-00731-z) contains supplementary material, which is available to authorized users.
Clinical outcomes varied according to the histologic subtypes of STS. Remarkable outcome was observed in alveolar soft-part sarcoma and solitary fibrous tumor.
* Jeong Eun Kim [email protected] Extended author information available on the last page of the article Vol.:(0123456789)
1 Introduction Soft tissue sarcomas (STSs), a rare and heterogeneous group of tumors with mesenchymal origin, account for approximately 1% of
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