Recent developments in regenerative ophthalmology
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cent developments in regenerative ophthalmology 1†
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Ye Shen , He Shen , Dongyu Guo , Xinghuai Sun , Yuan Sun , Nan Hong , Xiawei Wang , 1 1 1 1 1 1 1 Chen Xie , Yuan Zhao , Qin He , Le Jin , Yingying Wen , Bo Jiang , Chenying Yu , 1 5 3,4* Miaomiao Zhu , Feng Cai & Jianwu Dai 1
Department of Ophthalmology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310027, China; Department of Ophthalmology &Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China; 3 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 2
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Beijing 100101, China; Key Laboratory for Nano-Bio Interface Research, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China; Academic Department, Zhenjiang LeiYin Vision Regenerative Medicine Co., Ltd., Zhenjiang 212001, China
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Received March 9, 2020; accepted March 21, 2020; published online July 2, 2020
Regenerative medicine (RM) is one of the most promising disciplines for advancements in modern medicine, and regenerative ophthalmology (RO) is one of the most active fields of regenerative medicine. This review aims to provide an overview of regenerative ophthalmology, including the range of tools and materials being used, and to describe its application in ophthalmologic subspecialties, with the exception of surgical implantation of artificial tissues or organs (e.g., contact lens, artificial cornea, intraocular lens, artificial retina, and bionic eyes) due to space limitations. In addition, current challenges and limitations of regenerative ophthalmology are discussed and future directions are highlighted. regenerative medicine, regenerative ophthalmology, biomaterials, stem cells, tissue engineering, cell/tissue therapy Citation:
Shen, Y., Shen, H., Guo, D., Sun, X., Sun, Y., Hong, N., Wang, X., Xie, C., Zhao, Y., He, Q., et al. (2020). Recent developments in regenerative ophthalmology. Sci China Life Sci 63, https://doi.org/10.1007/s11427-019-1684-x
Overview Global estimates from a 2010 survey conducted by the World Health Organization suggest that approximately 285 million individuals worldwide suffer from visual impairment and 39 million from blindness (Pascolini and Mariotti, 2012). Regrettably, such loss of vision caused by many eye diseases is irreversible with currently available medical and surgical therapeutic modalities. Regenerative ophthalmology (RO) aims to restore function by replacing or regenerating tissues and organs using biomaterials, cells, and bioactive factors (Elisseeff et al., 2013). †Contributed equally to this work *Corresponding author (email: [email protected])
These novel clinical strategies (Figure 1) hold promise for the effective and efficient treatment of ophthalmic diseases. With rapid developments in tissue engineering technologies, RO researchers have devoted increasing efforts toward the regeneration of los
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