Recurrent Talaromyces marneffei Infection Presenting with Intestinal Obstruction in a Patient with Systemic Lupus Erythe
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CASE REPORT
Recurrent Talaromyces marneffei Infection Presenting with Intestinal Obstruction in a Patient with Systemic Lupus Erythematosus Yu-Kun Zhao Di-Qing Luo
. Jing-Ye Liu . Juan-Hua Liu
. Sha Lu . Hui-Hui Wu
.
Received: 8 January 2020 / Accepted: 22 June 2020 Springer Nature B.V. 2020
a daily dose of 400 mg for 3 months, leading to an excellent response. However, she died with unknown reason more than a year later. We also reviewed the literature on Talaromyces marneffei infection associated with SLE as well as intestinal talaromycosis alone.
Abstract Talaromyces marneffei is an important opportunistic pathogen mainly afflicting the HIVinfected patients, in rare instance, it could cause infection in non-HIV-infected individuals. We report a 51-year-old Chinese woman who, with histories of SLE for 14 years and disseminated talaromycosis for 4 years, occurred partial intestinal obstruction that was demonstrated to be caused by Talaromyces marneffei infection. The randomly amplified polymorphic DNA results of paraffin-embedded tissues from both the present episode and the previous infection suggested that the present infection was a recurrent. The patient was performed excision of involved intestine and treated with oral itraconazole at
Keywords Partial intestinal obstruction Talaromyces marneffei Recurrence Systemic lupus erythematosus
Introduction Talaromyces marneffei (T. marneffei), previously termed as Penicillium marneffei, is an emerging facultative dimorphic fungus, with multiple organ involvement [1, 2]. Its infection is one of the leading
A1 Handling Editor: Cunwei Cao. A2 Yu-Kun Zhao and Jing-Ye Liu contributed equally to the A3 present work. A4 A5 A6 A7 A8 A9
Y.-K. Zhao J.-H. Liu H.-H. Wu D.-Q. Luo (&) Department of Dermatology, The Eastern Division of The First Affiliated Hospital, Sun Yat-sen University, 183 Huangpu Rd. E., Guangzhou 510700, People’s Republic of China e-mail: [email protected]
A10 Y.-K. Zhao A11 e-mail: [email protected] A12 J.-H. Liu A13 e-mail: [email protected]
A16 A17 A18 A19 A20
J.-Y. Liu Department of Dermatology, Nancun Hospital, 185 Wenming Rd. Panyu District, Guangzhou 511442, People’s Republic of China e-mail: [email protected]
A21 A22 A23 A24 A25
S. Lu Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang Rd. W., Guangzhou 510120, People’s Republic of China e-mail: [email protected]
A14 H.-H. Wu A15 e-mail: [email protected]
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Mycopathologia
causes of mortality in HIV-infected patients in SouthEast Asia; however, talaromycosis also occurs in nonHIV-infected immunosuppressed individuals such as systemic lupus erythematosus (SLE) [3, 4]. To our knowledge, 17 cases of talaromycosis associated with SLE and 11 cases of talaromycosis with intestinal involvement alone had been reported [4–22]. Herein, we added a novel case of recurrent talaromycosis with intestinal involvement alone and reviewed the literature on T. marneffei infect
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