Reduced Alcohol Use Is Sustained in Patients Provided Alcohol-Related Counseling During Direct-Acting Antiviral Therapy
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ORIGINAL ARTICLE
Reduced Alcohol Use Is Sustained in Patients Provided Alcohol‑Related Counseling During Direct‑Acting Antiviral Therapy for Hepatitis C Yuval A. Patel1 · Jia Yao2 · Rae Jean Proeschold‑Bell2,3 · Donna Niedzwiecki4 · Elizabeth Goacher1 · Andrew J. Muir1,5 Received: 23 June 2020 / Accepted: 14 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Patients with chronic hepatitis C and risky/harmful alcohol use experience poor outcomes. Granular data evaluating whether alcohol counseling during hepatitis C treatment impacts longitudinal alcohol consumption are lacking. Aims To evaluate whether provider-delivered counseling in the context of direct-acting antiviral hepatitis C treatment associates with decreased longitudinal alcohol consumption. Methods We performed secondary data analysis from the Hep ART study including adults with hepatitis C who underwent provider-delivered counseling during direct-acting antiviral treatment between October 2014 and September 2017. Demographics and disease characteristics were summarized. Alcohol consumption, abstinence, and heavy drinking were evaluated in periods before, during, and after direct-acting antiviral treatment. Multivariate regression analyses were performed to evaluate the association of alcohol consumption with each 12-week time period for all patients and a subsample with cirrhosis. Results One hundred twenty-three patients were included; 41 had cirrhosis. Most patients were male (74.0%) and Black (58.5%). Alcohol consumption improved during direct-acting antiviral treatment and was notably sustained ( 24 weeks after treatment 7.69 g/day less, p = 0.0001). Conclusions Patients with chronic HCV and risky/harmful alcohol use given provider-delivered alcohol-related counseling during HCV treatment sustain decreased alcohol consumption patterns during and after treatment. Keywords Alcoholism · Alcohol drinking · Hepatitis C · Cirrhosis · Motivational interviewing · Cognitive behavioral therapy Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10620-020-06616-5) contains supplementary material, which is available to authorized users. * Yuval A. Patel [email protected]
1
Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
* Elizabeth Goacher [email protected]
2
Duke Center for Health Policy and Inequalities Research, Duke University, Durham, NC, USA
Jia Yao [email protected]
3
Duke Global Health Institute, Duke University, Durham, NC, USA
Rae Jean Proeschold‑Bell [email protected]
4
Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA
Donna Niedzwiecki [email protected]
5
Duke Clinical Research Institute, Duke University, Durham, NC, USA
Andrew J. Muir [email protected]
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Introduction Chronic hepatitis C virus (HCV) infection afflicts an estimated 71 million people worldwide [1] and can resu
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