Reducing Drug Attrition
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuitio
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James R. Empfield Michael P. Clark Editors
Reducing Drug Attrition
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Topics in Medicinal Chemistry
Editorial Board: P. R. Bernstein, Rose Valley, USA A. Buschauer, Regensburg, Germany G. I. Georg, Minneapolis, USA J. A. Lowe, Stonington, USA U. Stilz, Malov, Denmark C. T. Supuran, Sesto Fiorentino (Firenze), Italy A. K. Saxena, Lucknow, India
Aims and Scope Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the new topic-related series Topics in Medicinal Chemistry will cover all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. In references Topics in Medicinal Chemistry is abbreviated Top Med Chem and is cited as a journal.
More information about this series at http://www.springer.com/series/7355
James R. Empfield Michael P. Clark l
Editors
Reducing Drug Attrition
With contributions by C.G. Jackson A.S. Kalgutkar A.N.R. Nedderman P. Siegl D.K. Spracklin K.W. Ward
Editors James R. Empfield Vertex Pharmaceuticals Boston Massachusetts USA
Michael P. Clark Vertex Pharmaceuticals Boston Massachusetts USA
ISSN 1862-2461 ISSN 1862-247X (electronic) ISBN 978-3-662-43913-5 ISBN 978-3-662-43914-2 (eBook) DOI 10.1007/978-3-662-43914-2 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2014956013 # Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of gen
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