Reducing particle size of biodegradable nanomaterial for efficient curcumin loading
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Reducing particle size of biodegradable nanomaterial for efficient curcumin loading Ngoc Xuan Dat Mai1,2,3, Y Thi Dang1,2, Hanh Kieu Thi Ta1,2,4, Jong-Seong Bae5, Sungkyun Park6, Bach Thang Phan1,2, Fuyuhiko Tamanoi7,8, and Tan Le Hoang Doan1,2,*
1
Center for Innovative Materials and Architectures (INOMAR), Ho Chi Minh City 721337, Vietnam Vietnam National University-Ho Chi Minh City, Ho Chi Minh City 721337, Vietnam 3 Faculty of Physics and Engineering Physics, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City 721337, Vietnam 4 Faculty of Materials Science and Technology, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City 721337, Vietnam 5 Busan Center, Korea Basic Science Institute, Busan 46742, Republic of Korea 6 Department of Physics, Pusan National University, Busan 46241, Republic of Korea 7 Institute for Integrated Cell-Material Sciences (iCeMS), Institute for Advanced Study, Kyoto University, Kyoto 606 8501, Japan 8 Department of Microbiology, Immunology and Molecular Genetic, University of California, Los Angeles, Los Angeles, CA 90095, USA 2
Received: 27 June 2020
ABSTRACT
Accepted: 25 October 2020
Periodic mesoporous organosilica (PMO) are well known as highly potential materials in biomedical applications. In this work, biodegradable PMO nanoparticles, named E4S, which was incorporated of redox-responsive tetrasulfide bonds, were successfully synthesized with particle size smaller than 50 nm. We study the effect of synthetic conditions, especially the amounts of an alkaline catalyst on particle size and porosity of the nanomaterial. X-ray photoelectron spectroscopy, scanning electron microscope, N2 isotherm sorption, Fourier transform infrared (FT-IR) and thermogravimetric analysis techniques were applied to define structural characteristics. Curcumin, a highly hydrophobic, bioactive natural product, was chosen for loading onto the porous structure of E4S. The material exhibited high efficiency for curcumin loading with the capacity up to 1984 mg g-1. According to the loading investigation of the nanoparticles with various sizes, it is noted that the smallest particle shows the highest curcumin loading capacity which may result from small particle sizes and high specific surface area. These results suggest that ethane-tetrasulfide BPMO could be used as an excellent nanomaterial for curcumin loading.
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Springer Science+Business
Media, LLC, part of Springer Nature 2020
Handling Editor: Yaroslava Yingling.
Address correspondence to E-mail: [email protected]
https://doi.org/10.1007/s10853-020-05504-7
J Mater Sci
GRAPHICAL ABSTRACT
Introduction Mesoporous silica nanoparticle (MSN) has attracted much attention in a range of applications in biomedicine owing to the large surface area, adjustable pore volume, controllable particle sizes, high drug-loading capacity, good biocompatibility and versatile surface functionalization [1–8]. However, their main drawback for clinical applications is that the materials exhibit low d
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