Regenerative Engineering: Studies of the Rotator Cuff and other Musculoskeletal Soft Tissues
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Regenerative Engineering: Studies of the Rotator Cuff and other Musculoskeletal Soft Tissues Roshan James, Paulos Mengsteab and Cato T. Laurencin MRS Advances / FirstView Article / June 2016, pp 1 - 9 DOI: 10.1557/adv.2016.282, Published online: 28 April 2016
Link to this article: http://journals.cambridge.org/abstract_S2059852116002826 How to cite this article: Roshan James, Paulos Mengsteab and Cato T. Laurencin Regenerative Engineering: Studies of the Rotator Cuff and other Musculoskeletal Soft Tissues. MRS Advances, Available on CJO 2016 doi:10.1557/adv.2016.282 Request Permissions : Click here
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MRS Advances © 2016 Materials Research Society DOI: 10.1557/adv.2016.282
Regenerative Engineering: Studies of the Rotator Cuff and other Musculoskeletal Soft Tissues Roshan James1, 2, 6, Paulos Mengsteab1, 2, 4, Cato T. Laurencin1, 2, 3, 4, 5, 6 1
The Raymond and Beverly Sackler Center for Biomedical, Biological, Engineering and Physical Sciences, University of Connecticut Health Center, Farmington, CT 06030, U.S.A. 2 Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, U.S.A. 3 Department of Materials Science and Engineering, University of Connecticut, Storrs, CT 06269, U.S.A. 4 Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, U.S.A. 5 Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06269, U.S.A. 6 Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, U.S.A. ABSTRACT ‘Regenerative Engineering’ is the integration of advanced materials science, stem cell science, physics, developmental biology and clinical translation to regenerate complex tissues and organ systems. Advanced biomaterial and stem cell science converge as mechanisms to guide regeneration and the development of prescribed cell lineages from undifferentiated stem cell populations. Studies in somite development and tissue specification have provided significant insight into pathways of biological regulation responsible for tissue determination, especially morphogen gradients, and paracrine and contact-dependent signaling. The understanding of developmental biology mechanisms are shifting the biomaterial design paradigm by the incorporation of molecules into scaffold design and biomaterial development that are specifically targeted to promote the regeneration of soft tissues. Our understanding allows the selective control of cell sensitivity, and a temporal and spatial arrangement to modulate the wound healing mechanism, and the development of cell phenotype leading to the patterning of distinct and multi-scale tissue systems. Building on the development of mechanically compliant novel biomaterials, the integration of spatiotemporal control of biological, chemical and mechanica
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