Regional brain atrophy in overactive bladder syndrome: a voxel based morphometry study
- PDF / 808,870 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 82 Downloads / 155 Views
UROLOGY - ORIGINAL PAPER
Regional brain atrophy in overactive bladder syndrome: a voxel based morphometry study Long Zuo1 · Yang Zhou1 · Shuangkun Wang1 · Biao Wang2 · Hua Gu1 · Jingnan Chen3 Received: 10 June 2020 / Accepted: 13 August 2020 © Springer Nature B.V. 2020
Abstract Objectives To investigate whether patients with overactive bladder syndrome (OAB) have brain volume changes using voxel-based morphometry (VBM) and correlations with clinical tests. Methods With institutional review board approval and after obtaining written informed consent, structural magnetic resonance imaging data were prospectively acquired in 28 patients and 28 control subjects. OAB symptoms were assessed using the OAB symptom score (OABSS) scale. The gray matter volume (GMV) of each voxel was compared between the two groups while controlling for the effects of age, sex, and education level. Correlation analysis was performed to identify correlations between abnormal GMV regions and OABSS scores in patients. Multiple comparisons were corrected using a false discovery rate (FDR) method. Results Patients with OAB exhibited a GMV reduction in the right cerebellum, bilateral hippocampus, left insula, right superior temporal gyrus, left anterior cingulate gyrus, bilateral caudate nucleus and right middle frontal gyrus. Furthermore, there was a significant negative correlation between the local GMV of the right cerebellar hemisphere and OABSS score. Conclusions Patients with OAB have abnormal GMV in brain regions localized within the brain-bladder control network. It deepens our understanding of the structural changes in the brain area of the network. The patterns of structural reorganization in patients with OAB may provide useful information in the neuropathological mechanisms of the OAB. Keywords Overactive bladder syndrome · Brain-bladder control network · Voxel-based morphometry · Gray matter volume · Structural reorganization
Introduction Overactive bladder syndrome (OAB) is defined as a symptom complex including urgency, with or without urge incontinence, but usually with frequency and nocturia. OAB is a
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11255-020-02614-8) contains supplementary material, which is available to authorized users. * Shuangkun Wang [email protected] 1
Department of Radiology, Beijing Chao‑Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing 100020, China
2
Department of Urology, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing, China
3
School of Economics and Management, Beihang University, Beijing, China
prevalent and costly condition that greatly impairs living quality of patients worldwide [1]. In order to explore the etiology of OAB, researchers propose many hypotheses. Using blood oxygenation-level dependent (BOLD) imaging from functional magnetic resonance imaging (fMRI), emerging research on central pathophysiologic mechanisms attracts more and more attention. The
Data Loading...
