REGO-ACT: assessment of physical activity during treatment with regorafenib for metastatic colorectal cancer
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Wien Klin Wochenschr https://doi.org/10.1007/s00508-020-01703-z
REGO-ACT: assessment of physical activity during treatment with regorafenib for metastatic colorectal cancer Gudrun Piringer · Laurenz Vormittag · Leopold Öhler · Birgit Grünberger · Johannes Meran · Marlies Moshammer · Johannes Andel · Wolfgang Eisterer · Vera Trommet · Josef Thaler
Received: 3 February 2020 / Accepted: 6 June 2020 © Springer-Verlag GmbH Austria, part of Springer Nature 2020
Summary Background A frequent side effect of the multikinase inhibitor regorafenib is fatigue. Physical activity has shown potential in reducing cancer-related fatigue. Methods This non-interventional pilot study assessed physical activity levels of metastatic colorectal cancer (mCRC) patients treated with regorafenib based on median daily step counts measured at 1-week intervals using a pedometer. The study further evaluated
Dr. G. Piringer () · V. Trommet · J. Thaler Department of Internal Medicine IV, Klinikum Wels-Grieskirchen, Grieskirchnerstraße 42, 4600 Wels, Austria [email protected] L. Vormittag · L. Öhler Department of Internal Medicine I, St. Josef Hospital Vienna, Vienna, Austria B. Grünberger · J. Meran Department of Internal Medicine, Hospital of The Merciful Brothers, Vienna, Austria B. Grünberger Department of Internal Medicine, Landesklinikum Wiener Neustadt, Wiener Neustadt, Austria M. Moshammer Bayer Austria GmbH, Vienna, Austria J. Andel Department of Internal Medicine II, Landeskrankenhaus Steyr, Steyr, Austria W. Eisterer Department of Internal Medicine V, Innsbruck Medical University, Innsbruck, Austria Department of Internal Medicine, Klinikum Klagenfurt, Klagenfurt, Austria Dr. G. Piringer · J. Thaler Johannes Kepler University Linz, Linz, Austria
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relations between physical activity levels and fatigue, quality of life (QoL) and progression-free survival. Results Pedometer data were available for 22 out of 25 enrolled patients. The numbers of days with available pedometer data ranged from 6 to 100 days. The overall median daily step count was 2357 (range 10–14,931), with substantial interindividual and intraindividual variations. Interindividual median weekly step counts were in the range of 5000–7000 in some, 2000–3000 in others, and several hundreds or less in a few patients. Intraindividual daily step counts also varied by several thousands of steps. Step counts in weeks in which patients reported fatigue were well within the range of or even higher than step counts in adjacent weeks, indicating a lack of correlation. The risk of disease progression was also independent of median weekly step counts; however, significant correlations were seen between QoL and step counts. Conclusion Despite the severity of their disease patients showed remarkable levels of walking activity. In view of the highly individual activity levels, exercise prescriptions for seriously ill patient populations should be personalized to the specific needs and preferences of each individual patient. Keywords Fatigue · Step counts · Pedometer · Activ
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