Relationship Between Magnetic Resonance T2-Mapping and Matrix Metalloproteinase 1,3 in Knee Osteoarthritis
- PDF / 1,638,472 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 59 Downloads / 182 Views
ORIGINAL ARTICLE
Relationship Between Magnetic Resonance T2‑Mapping and Matrix Metalloproteinase 1,3 in Knee Osteoarthritis Lei Shi1 · Kexin Wang1 · Jinghong Yu1 · Mingkai Li1 · Guangmei Men1 · Gang Ma2 · Xing Wang3 Received: 29 February 2020 / Accepted: 16 October 2020 © The Author(s) 2020
Abstract Objective To investigate the relationship between quantitative analysis of MRI (T2-mapping) and the expression of matrix metalloproteinase (MMP-1, MMP-3) in osteoarthritis of the knee joint and the role of MMP-1,3 in the pathogenesis of osteoarthritis. Methods Thirty cases of knee osteoarthritis (KOA) patients with total knee arthroplasty (TKA) (lesion group) and 30 healthy adult volunteers (control group) were scanned with 1.5 T routine MR and T2-mapping, and their T2 values were measured and statistically analyzed. The pathological examination of the knee cartilage that was replaced during the operation and the immunohistochemical assay were used to measure the expression of MMP-1,3. The correlation between the T2 value of magnetic resonance imaging and the expression of MMP-1,3 was analyzed. Results (1) According to the Recht grading standard for magnetic resonance, the T2 value of magnetic resonance increased significantly with the increase of cartilage degeneration. The differences in T2 values between each level and the normal group were statistically significant (P
Data Loading...
