Relationship between Methylation of FHIT and CDH13 Gene Promoter Region and Liver Cancer
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40(3):1-6,2020
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Relationship between Methylation of FHIT and CDH13 Gene Promoter Region and Liver Cancer* Ao-dun TUOYA1, Dong-xue WANG2, Yu-shu XING3, 4, Rui-jun LIU1, Yu-xia HU3, 4, Meng-di ZHANG2, 4, Tu-ya BAI2, 4, Xiao-li LV2, 4, Jun LI3, 4, Fu-hou CHANG2, 3, 4# 1 The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, China 2 Department of Pharmacology of Pharmaceutical College, Inner Mongolia Medical University, Hohhot 010010, China 3 The Center for New Drug Safety Evaluation and Research of Inner Mongolia Medical University, Hohhot 010010, China 4 Inner Mongolia Research Center for Drug Screening, Hohhot 010110, China Huazhong University of Science and Technology 2020
Summary: In order to demonstrate the relationship between methylation of fragile histidine triad (FHIT) and T-cadherin/H-cadherin (CDH13) genes and liver cancer, the methylation status of FHIT and CDH13 was detected in healthy individuals and in Mongolian and Han patients with liver cancer. The phenol-chloroform method was used to extract genomic DNA. The methylation specific polymerase chain reaction method was applied to detect the methylation status of FHIT and CDH13. The relationship between smoking and alcohol consumption and gene (FHIT and CDH13) methylation was analyzed. There was significant difference in methylation rate of FHIT (72.67%, 34.67%) and CDH13 (72.0%, 28.0%) between liver cancer patients and healthy individuals of Mongolian descent (P
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