Relationship Between Quantitative Ultrasound Parameters at the Calcaneus and Health-Related Quality of Life in Postmenop
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ORIGINAL RESEARCH
Relationship Between Quantitative Ultrasound Parameters at the Calcaneus and Health-Related Quality of Life in Postmenopausal Italian Women: The FEDRO Study Stefano Gonnelli • C. Caffarelli • L. Tanzilli A. Cadirni • G. Guglielmi • S. Rossi • R. Nuti
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Received: 6 March 2013 / Accepted: 9 July 2013 Ó Springer Science+Business Media New York 2013
Abstract Reduced bone mineral density has been reported to adversely affect health-related quality of life (HRQoL) in postmenopausal women without vertebral fracture. To date, no data exist in the literature about any possible influences of quantitative ultrasonographic (QUS) parameters on HRQoL. This study aimed to assess whether QUS parameters at the calcaneus may be associated with HRQoL. In 1,812 ambulatory postmenopausal women aged 60 years or over, we measured HRQoL by the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) and stiffness index using QUS at the calcaneus. By grouping the 1,812 women on the basis of stiffness index, a highly significant (p \ 0.001) difference was found for both total QUALEFFO and five domains of the QUALEFFO, whereas for the Pain and Mental Function domains the significance was modest. Stiffness was inversely associated (p \ 0.01) with total QUALEFFO and with all QUALEFFO domains. In stepwise multiple logistic regression analysis stiffness values were negatively associated with both QUALEFFO total score and all domains of the QUALEFFO-41. The presence
S. Gonnelli (&) C. Caffarelli L. Tanzilli A. Cadirni R. Nuti Department of Internal Medicine, Endocrine-Metabolic Science and Biochemistry, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100 Siena, Italy e-mail: [email protected] G. Guglielmi Department of Radiology, Scientific Institute Hospital, Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy S. Rossi Department of Physiopathology, Experimental Medicine and Public Health, Research Center for Health Promotion and Education, University of Siena, Siena, Italy
of concomitant diseases was associated with a worsening of HRQoL in all domains of the QUALEFFO, whereas age was associated with the three domains of physical function but not with the Pain and Mental Function domains. Our study suggests that in postmenopausal women there is a close relationship between bone status measured by QUS at the calcaneus and quality of life assessed by the QUALEFFO. Therefore, QUS at the calcaneus may have a role in early strategies to prevent HRQoL impairment and osteoporosis exacerbation. Keywords Quantitative ultrasound Health-related quality of life Postmenopausal women QUALEFFO-41
Introduction Osteoporosis, a multifactorial systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to increased bone fragility, is a worldwide public health problem [1]. The clinical and economic burdens of osteoporosis are mainly determined by the occurrence of fractures and consequent morbidity [2]. Vertebral fract
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