Relationship of myocardial scar with cardiovascular disease risk factors in the diabetes control and complications trial
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BioMed Central
Open Access
Moderated poster presentation
Relationship of myocardial scar with cardiovascular disease risk factors in the diabetes control and complications trial (DCCT)/epidemiology of diabetes interventions and complications (EDIC) study Evrim B Turkbey*1, Patricia A Cleary2, Jye-Yu Backlund2, John M Lachin2, David M Nathan3, Rob J van der Geest4, Joao AC Lima5 and David A Bluemke1 Address: 1NIH, Bethesda, MD, USA, 2George Washington University, Rockville, MD, USA, 3Massachusetts General Hospital, Boston, MA, USA, 4Leiden University Medical Center, Leiden, Netherlands and 5Johns Hopkins University, Baltimore, MD, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):M6
doi:10.1186/1532-429X-12-S1-M6
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/M6 © 2010 Turkbey et al; licensee BioMed Central Ltd.
Introduction Type 1 diabetes is associated with an increased risk of myocardial infarction. Risk factors related to the presence of myocardial scar detected by MRI have not been explored in patients with type 1 diabetes.
excluded from the gadolinium study. Images were evaluated for the presence and absence of myocardial scar as well as typical (infarct related) and atypical (non-infarct related) pattern of scar.
Results Purpose To determine the prevalence of myocardial scar and to examine cardiovascular disease (CVD) risk factors associated with myocardial scar in a large multi-center study.
Methods The EDIC study is the observational follow-up (1994present) of the DCCT cohort. The DCCT (1983-93) was a controlled clinical trial of intensive versus conventional diabetes treatment in 1441 type 1 diabetic subjects. A total of 1019 DCCT/EDIC subjects underwent cardiovascular MRI at 28 centers in the USA and Canada during the 14th year of EDIC. MRI examination, centrally read, included left ventricular (LV) mass, volume and myocardial scar evaluation. A total of 757 eligible patients underwent 15 minute myocardial delayed enhancement MRI following intravenous administration of 0.15 mmol/kg dose of gadolinium contrast. Subjects with gadolinium allergy, dialysis, transplant or GFR < 60 mL/min/1.73 m2 were
743 studies were available for evaluation of myocardial scar (14 non-diagnostic studies). The mean age was 49 ± 7 years, 58% were men, and diabetes duration was 27 ± 5 years. The prevalence of any myocardial scar was 4.3% (32/743) with 16 typical and 16 atypical patterns. Men had a higher prevalence of scar compared to women (5.8% vs. 2.2%, respectively; p < 0.05). Older patients and those with hypertension, lower ejection fraction, increased LV mass and higher albumin excretion rate had a significantly hig
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