Renal Cell Carcinoma Molecular Features and Treatment Updates

This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in mo

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Renal Cell Carcinoma Molecular Features and Treatment Updates

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Renal Cell Carcinoma

Mototsugu Oya Editor

Renal Cell Carcinoma Molecular Features and Treatment Updates

Editor Mototsugu Oya Department of Urology Keio University School of Medicine Tokyo, Japan

ISBN 978-4-431-55530-8 ISBN 978-4-431-55531-5 DOI 10.1007/978-4-431-55531-5

(eBook)

Library of Congress Control Number: 2017932530 © Springer Japan KK 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Japan KK The registered company address is: Chiyoda First Bldg. East, 3-8-1 Nishi-Kanda, Chiyoda-ku, Tokyo 101-0065, Japan

Preface

Renal Cell Carcinoma: Molecular Features and Treatment Updates provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) to practitioners and researchers with an interest in this disease. This book covers all topics from basic biology and pathology to clinical practice. Clinical topics include etiology, diagnosis, and all treatment options. The book also makes a strong effort to catch up with the key, most up-to-date advances in information about molecular bases and targeted therapy of this neoplasm. RCC therapy is the most advanced field in terms of molecular-targeted therapy. Medical oncologists as well as urologists have begun to be interested in this area. Basic researchers who focus on cancer metabolism, cancer genetics and epigenetics, vascular biology, and cancer immunotherapy may also be interested and inspired by this book. In the past decade, treatment options for renal cell carcinoma have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. RCC is resistant to chemotherapy and radiotherapy and had been a rare cancer where immunotherapy including interleukin-2 or inter