Renal-type clear cell carcinoma of the prostate: a diagnostic challenge
- PDF / 1,240,368 Bytes
- 4 Pages / 595.276 x 793.701 pts Page_size
- 13 Downloads / 184 Views
CASE REPORT
Open Access
Renal-type clear cell carcinoma of the prostate: a diagnostic challenge Shashikant C. U. Patne1*, Nidhi Johri1, Richa Katiyar1, Sameer Trivedi2 and Uday Shankar Dwivedi2
Abstract A 72-year-old male presented with urinary symptoms. His serum prostate specific antigen level was 65.2 ng/ml. His radical prostatectomy specimen showed clear cell lesion reminiscent of the clear cell renal cell carcinoma along with acinar type of prostatic adenocarcinoma, Gleason score 4 + 4. The lesional clear cells were positive for pancytokeratin, epithelial membrane antigen, CD10, vimentin, and AMACR while negative for 34βE12, CK7, prostate specific antigen, and PAX8. The final diagnosis was renal-type clear cell carcinoma of the prostate. A follow-up of 20 months did not show metastasis. We herein report fifth case of renal-type clear cell carcinoma of the prostate. Keywords: Renal cell carcinoma, Male, Prostate-specific antigen, Prostatectomy, Prostatic neoplasms
Background Occurrence of clear cell lesions in the prostate is rare and diagnostically challenging with variety of possible diagnoses. These include clear cell variants of commonly seen prostatic adenocarcinoma and transitional cell carcinoma together with uncommonly encountered clear cell carcinoma of mullerian type, metastatic renal cell carcinoma, and a recently described entity, renal-type clear cell carcinoma (RTCCC) of the prostate [1, 2]. RTCCC occurring in the prostate is an extremely unusual malignant tumor with only four previously published case reports [2–5]. We herein report fifth case of RTCCC of the prostate and review pertinent literature. Case presentation A 72-year-old man came to Urology OPD for evaluation of urinary frequency, urgency, and difficulty. His rectal examination revealed grade II enlargement of the prostate that was firm on palpation. His urine examination was positive for occult blood and 50–70 pus cells/high power fields. His serum prostate specific antigen (PSA) level was 65.2 ng/ml (normal
Data Loading...
