Reproductive technologies, female infertility, and the risk of imprinting-related disorders
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RESEARCH
Reproductive technologies, female infertility, and the risk of imprinting‑related disorders Patricia Fauque1* , Jacques De Mouzon2, Aviva Devaux3, Sylvie Epelboin4, Marie‑José Gervoise‑Boyer5, Rachel Levy6, Morgane Valentin7, Géraldine Viot8, Arianne Bergère9, Claire De Vienne9, Philippe Jonveaux9 and Fabienne Pessione9
Abstract Background: Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes take place at times when epigenetic reprogramming/imprinting are occurring, there is concern that ART can affect genomic imprints. However, little is currently known about the risk of imprinting defects according to the type of ART or the type of underlying female infertility. From the French national health database, a cohort of 3,501,495 singletons born over a 5-year period (2013–2017) following fresh embryo or frozen embryo transfers (fresh-ET or FET from in vitro fertilization), intrauterine insemina‑ tion, or natural conception was followed up to early childhood. Based on clinical features, several syndromes/diseases involving imprinted genes were monitored. The effects of ART conception and the underlying cause of female infertil‑ ity were assessed. Results: Compared with infants conceived naturally, children born after fresh-ET had a higher prevalence of imprint‑ ing-related diseases, with an aOR of 1.43 [95% CI 1.13–1.81, p = 0.003]. Namely, we observed an increased risk of neonatal diabetes mellitus (1.96 aOR [95% CI 1.43–2.70], p 4% of births in some European countries [1].
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Fauque et al. Clin Epigenet
(2020) 12:191
Even though most of these children are considered healthy, there is increasing awareness about the potential consequences of ART on a number of complications potentially linked to epigenetic deregulation [2]. Epidemiological studies suggest that sing
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