Resistance to aspirin is increased by ST-elevation myocardial infarction and correlates with adenosine diphosphate level
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BioMed Central
Open Access
Original clinical investigation
Resistance to aspirin is increased by ST-elevation myocardial infarction and correlates with adenosine diphosphate levels Catharina Borna1, Eduardo Lazarowski2, Catharina van Heusden2, Hans Öhlin1 and David Erlinge*1 Address: 1Department of Cardiology, Heart & Lung Division, Lund University Hospital, Sweden and 2Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, USA Email: Catharina Borna - [email protected]; Eduardo Lazarowski - [email protected]; Catharina van Heusden - [email protected]; Hans Öhlin - [email protected]; David Erlinge* - [email protected] * Corresponding author
Published: 26 July 2005 Thrombosis Journal 2005, 3:10
doi:10.1186/1477-9560-3-10
Received: 06 June 2005 Accepted: 26 July 2005
This article is available from: http://www.thrombosisjournal.com/content/3/1/10 © 2005 Borna et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
aspirinacute coronary syndromesplateletsADP
Abstract Background: To be fully activated platelets are dependent on two positive feedback loops; the formation of thromboxane A2 by cyclooxygenase in the platelets and the release of ADP. We wanted to evaluate the effect of aspirin on platelet function in patients with acute coronary syndromes and we hypothesized that increased levels of ADP in patients with acute coronary syndromes could contribute to aspirin resistance. Methods: Platelet activity in 135 patients admitted for chest pain was assessed with PFA-100. An epinephrine-collagen cartridge (EPI-COLL) was used for the detection of aspirin resistance together with an ADP-collagen cartridge (ADP-COLL). ADP was measured with hplc from antecubital vein samples. Three subgroups were compared: chest pain with no sign of cardiac disease (NCD), NonST-elevation myocardial infarction (NSTEMI) and STEMI. Results: Platelet activation was increased for the STEMI group compared NCD. Aspirin resistance defined as
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