Resistance to Photodynamic Therapy in Cancer
This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, imm
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Volume 5
Series Editor Benjamin Bonavida Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine and UCLA Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA 90095
For several decades, treatment of cancer consisted of chemotherapeutic drugs, radiation, and hormonal therapies. Those were not tumor specific and exhibited severe toxicities in many cases. But during the last several years, targeted cancer therapies have been developed. Targeted cancer therapies—sometimes called “molecularly targeted drugs—are drugs or other agents (e.g., anti-bodies) that block the growth and spread of cancer by interfering with specific gene products that regulate tumor cell growth and progression”. We have witnessed in the last decade a significant explosion in the development of targeted cancer therapies developed against various specific cancers. These include drugs/antibodies that interfere with cell growth signaling or tumor blood vessel development, promote the cell death of cancer cells, stimulate the immune system to destroy specific cancer cells, and deliver toxic drugs to cancer cells. One of the major problems that arises following treatment with both conventional therapies and targeted cancer therapies is the development of resistance, preexisting in a subset of cancer cells or cancer stem cells and/or induced by the treatments. Tumor cell resistance to therapies remains a major problem and several strategies are being considered to reverse the resistance to various manipulations. Resistance to Targeted Anti-Cancer Therapeutics focuses on the basic and translational research behind the molecular mechanisms of resistance found in many kinds of anti-cancer therapeutics. For more information about this series, go to http://www.springer.com/series/11727
Valentina Rapozzi • Giulio Jori Editors
Resistance to Photodynamic Therapy in Cancer
Editors Valentina Rapozzi Medical and Biological Sciences University of Udine
Udine Italy
Giulio Jori Department of Biology University of Padova
Padova Italy
ISSN 2196-5501 ISSN 2196-551X (electronic) Resistance to Targeted Anti-Cancer Therapeutics ISBN 978-3-319-12729-3 ISBN 978-3-319-12730-9 (eBook) DOI 10.1007/978-3-319-12730-9 Library of Congress Control Number: 2014958752 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, t
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