Resting-State Magnetoencephalography Reveals Neurobiological Bridges Between Pain and Cognitive Impairment
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ORIGINAL RESEARCH
Resting-State Magnetoencephalography Reveals Neurobiological Bridges Between Pain and Cognitive Impairment Yoshihito Shigihara
. Hideyuki Hoshi . Keisuke Fukasawa .
Sayuri Ichikawa . Momoko Kobayashi . Yuki Sakamoto . Kazuyuki Negishi . Rika Haraguchi . Shin Konno
Received: September 15, 2020 / Accepted: October 15, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Pain has been identified as a risk factor for cognitive dysfunction, which in turn affects pain perception. Although pain, cognitive dysfunction, and their interaction are clinically important, the neural mechanism connecting the two phenomena remains unclear. Methods: The resting-state brain activity of 38 participants was measured using magnetoencephalography before and after the patients underwent selective nerve root block (SNRB) for the treatment of their pain. We then assessed the extent to which these data correlated with the subjective levels of pain experienced by the patients across SNRB based on the visual analogue scale and the cognitive status of the Y. Shigihara (&) H. Hoshi Precision Medicine Centre, Hokuto Hospital, Obihiro, Japan e-mail: [email protected] Y. Shigihara M. Kobayashi Y. Sakamoto Precision Medicine Centre, Kumagaya General Hospital, Kumagaya, Japan K. Fukasawa S. Ichikawa K. Negishi R. Haraguchi Clinical Laboratory, Kumagaya General Hospital, Kumagaya, Japan S. Konno Department of Orthopaedics, Kumagaya General Hospital, Kumagaya, Japan
patients measured after SNRB using the Japanese versions of the Mini-Mental State Examination (MMSE-J). Results: Slow oscillations (delta) in the right precentral gyrus, right middle temporal gyrus, and left superior frontal gyrus were negatively correlated with the subjective level of pain, and fast oscillations (gamma) in the right insular cortex and right middle temporal gyrus before SNRB were negatively correlated with the MMSE-J score afterwards. These correlations disappeared after SNRB. Conclusion: The presently observed changes in neural activity, as indicated by oscillation changes, might represent the transient bridge between pain and cognitive dysfunction in patients with severe pain. Our findings underscore the importance of treating pain before a transient diminishment of cognitive function becomes persistent. Keywords: Cognitive dysfunction; Dementia; Magnetoencephalography; Neural mechanism; Pain; Resting-state brain activities; Selective nerve root blocks; Spontaneous neural oscillations
Pain Ther
Key Summary Points Why carry out this study? Both pain and cognitive impairment are common symptoms that often coexist, especially in older individuals. Although these two symptoms interact with each other, the neural mechanisms bridging them remain unclear. The present study used the functional neuroimaging technique of magnetoencephalography to gain insight into the neural mechanisms. What was learned from the study? Resting-state brain activity recorded before and after the surgical treatment of severe pain correlated with subjective l
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