Rheumatoid Arthritis Methods and Protocols
This volume provides a summary of the standard laboratory protocols and methodology commonly used in basic and translational studies in the field of rheumatoid arthritis (RA) treatment. Chapters detail including basic RA models, evaluation of disease acti
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Shuang Liu Editor
Rheumatoid Arthritis Methods and Protocols
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes http://www.springer.com/series/7651
Rheumatoid Arthritis Methods and Protocols
Edited by
Shuang Liu Department of Pharmacology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan
Editor Shuang Liu Department of Pharmacology Ehime University Graduate School of Medicine Toon, Ehime, Japan
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-8801-3 ISBN 978-1-4939-8802-0 (eBook) https://doi.org/10.1007/978-1-4939-8802-0 Library of Congress Control Number: 2018954053 © Springer Science+Business Media, LLC, part of Springer Nature 2018, corrected publication 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Rheumatoid arthritis (RA) is the most common autoimmune inflammatory arthritis in adults, affecting almost 1% of the world’s population. At present, fewer than 30% of patients show robust responses to treatments. These treatments are associated with a number of adverse side effects, including disease relapse and bone deformation of individual joints. Thus, additional RA- and target-specific preclinical studies are required and further optimization of the treatments is necessary prior to the clinical setting. Rheumatoid Arthritis: Methods and Protocols summarizes the standard laboratory protocols and methodology commonly used in basic and translational studies in the field of RA treatment, including the establishment of basic
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