Risk Factors for Poor Outcome in Patients with Severe Viral Pneumonia on Chest CT during the COVID-19 Outbreak: a Perspe
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COVID-19
Risk Factors for Poor Outcome in Patients with Severe Viral Pneumonia on Chest CT during the COVID-19 Outbreak: a Perspective from Iran Amir H. Davarpanah 1,2 & Reyhaneh Asgari 1 & Yashar Moharamzad 1 & Arash Mahdavi 1 & Alireza Abrishami 1 Sayyedmojtaba Nekooghadam 1 & Ali Sabri 3 & Ehsan Zarei 1 & Mehdi Khazaei 1 & Morteza Sanei Taheri 1,4
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Accepted: 6 August 2020 / Published online: 19 August 2020 # Springer Nature Switzerland AG 2020
Abstract We investigated significant predictors of poor in-hospital outcomes for patients admitted with viral pneumonia during the COVID-19 outbreak in Tehran, Iran. Between February 22 and March 22, 2020, patients who were admitted to three university hospitals during the COVID-19 outbreak in Tehran, Iran were included. Demographic, clinical, laboratory, and chest CT scan findings were gathered. Two radiologists evaluated the distribution and CT features of the lesions and also scored the extent of lung involvement as the sum of three zones in each lung. Of 228 included patients, 45 patients (19.7%) required ICU admission and 34 patients (14.9%) died. According to regression analysis, older age (OR = 1.06; P < 0.001), blood oxygen saturation (SpO2) < 88% (OR = 2.88; P = 0.03), and higher chest CT total score (OR = 1.10; P = 0.03) were significant predictors for inhospital death. The same three variables were also recognized as significant predictors for invasive respiratory support: SpO2 < 88% (OR = 3.97, P = 0.002), older age (OR = 1.05, P < 0.001), and higher CT total score (OR = 1.13, P = 0.008). Potential predictors of invasive respiratory support and in-hospital death in patients with viral pneumonia were older age, SpO2 < 88%, and higher chest CT score. Keywords Tomography, X-ray computed . Pneumonia . COVID-19 . Prognosis . Patient outcome assessment
Introduction Since late December 2019 when a new coronavirus was isolated from a group of patients diagnosed with pneumonia in
China, the world has observed rapid expansion of this novel contagious virus called SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). The disease caused by this novel virus is called coronavirus disease (COVID-19), and its
* Amir H. Davarpanah [email protected]
Ali Sabri [email protected]
* Morteza Sanei Taheri [email protected]; [email protected]
Ehsan Zarei [email protected]
Reyhaneh Asgari [email protected]
Mehdi Khazaei [email protected]
Yashar Moharamzad [email protected]
1
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Arash Mahdavi [email protected]
2
Department of Radiology and Imaging Sciences, Emory University Hospital, School of Medicine, Emory University, Atlanta, GA 30322, USA
3
Niagara Health, McMaster University, Hamilton, Ontario, Canada
4
Department of Radiology, Shohada Hospital, Tajrish Sq, Tehran 1445613131, Iran
Alireza Abrishami [email protected] Sayyedmojtaba Nekooghadam [email protected]
SN Compr. Clin. Med. (2020) 2:1366–1376
clinical presentation spectrum ranges
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