Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study
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Journal of Translational Medicine Open Access
RESEARCH
Risk factors for severe COVID‑19 in middle‑aged patients without comorbidities: a multicentre retrospective study Peng Wang1†, Jing Sha1†, Mei Meng2†, Cuiyan Wang3†, Qingchun Yao1, Zhongfa Zhang4, Wenqing Sun5, Xingguang Wang6, Guoqiang Qie1, Xue Bai1, Keke Liu7 and Yufeng Chu1*
Abstract Background: Information regarding characteristics and risk factors of COVID-19 amongst middle-aged (40–59 years) patients without comorbidities is scarce. Methods: We therefore conducted this multicentre retrospective study and collected data of middle-aged COVID-19 patients without comorbidities at admission from three designated hospitals in China. Results: Among 119 middle-aged patients without comorbidities, 18 (15.1%) developed into severe illness and 5 (3.9%) died in hospital. ARDS (26, 21.8%) and elevated D-dimer (36, 31.3%) were the most common complications, while other organ complications were relatively rare. Multivariable regression showed increasing odds of severe illness associated with neutrophil to lymphocyte ratio (NLR, OR, 11.238; 95% CI 1.110–1.382; p 39 ℃), expectoration, myalgia and dyspnea were more common in severe cases as compared with non-severe cases (p
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