Role of Cervical Phosphorylated Insulin-Like Growth Factor-Binding Protein 1 (phIGFBP1) for Prediction of Successful Ind
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ORIGINAL ARTICLE
Role of Cervical Phosphorylated Insulin‑Like Growth Factor‑Binding Protein 1 (phIGFBP1) for Prediction of Successful Induction Among Primigravida with Prolonged Pregnancy Aayushi Rathore1 · Richa Sharma1 · Rajarshi Kar2 · Anupama Tandon3 · Amita Suneja1 · Kiran Guleria1 Received: 1 April 2020 / Accepted: 25 August 2020 © Federation of Obstetric & Gynecological Societies of India 2020
Abstract Purpose of the Study To estimate and to compare the levels of cervical phIGFBP-1 among primigravida with prolonged pregnancy, with and without successful induction of labor (IOL). Methods A diagnostic study (cross-sectional study design) was conducted in our institution from November 2016 to April 2018 on 84 primigravida at ≥ 41 weeks with uncomplicated singleton pregnancy. The results were analyzed using SPSS software and receiver operating characteristics curves to determine the best cutoff using Youden Index. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive (+ LR) and negative likelihood ratio (− LR) were calculated. P value 7.8 µg/l) were 0.87, 0.87, 0.89, 0.85, 6.76 and 0.15, respectively. Using logistic regression analysis, phIGFBP-1 was found to be the best predictor of successful IOL (OR 44.200; 95% CI 12.378–157.831, p 5 uterine contractions in 10 min), meconium-stained liquor and aspiration, failed IOL and fetal distress (fetal heart rate
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