Role of menthol in treatment of candidial napkin dermatitis
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Role of menthol in treatment of candidial napkin dermatitis Ali Mohammad Sabzghabaee, Firouzeh Nili, Alireza Ghannadi, Nastaran Eizadi-Mood, Maryam Anvari Isfahan, Iran
Methods: A pilot clinical trial was conducted in Iran at the Tehran University of Medical Sciences. Eligible neonates with a diagnosis of candidial ND who did not require critical care or systematic antifungal and antiinflammatory drugs were included in the study. Overall, 84 patients were randomly allocated into two groups: menthol group (n=42) receiving standard therapy (topical clotrimazole) plus menthol drops applied topically and control group (n=42) receiving standard therapy plus a placebo. Thirty-five neonates in each group finished the course of study and were analyzed for skin rash using Munz and Concannon rash scoring methods before therapy and on the 1st, 3rd, 5th and 7th day after the treatments. Results: Demographic data and the baseline total skin rash score were not significantly different between the menthol and control groups. The total course of therapy for complete healing was found to be shorter in the menthol group (4.3±1.6 vs. 6.9±1.8 days, P=0.0001) and erythema and pustules had a significant (P=0.0001) relief in this group. During the study no severe adverse effects of the drug were observed. Conclusion: Topical application of menthol may be effective in treatment of candidial ND. World J Pediatr 2011;7(2):167-170
Author Affiliations: Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran (Sabzghabaee AM, Eizadi-Mood N); Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran (Nili F); Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran (Ghannadi A); Staff Pharmacist, Valiasr Pediatric Hospital, Tehran, Iran (Anvari M) Corresponding Author: Nastaran Eizadi-Mood, MD, Associate Professor of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran (Email: [email protected]) doi: 10.1007/s12519-011-0253-0 ©Children's Hospital, Zhejiang University School of Medicine, China and Springer-Verlag Berlin Heidelberg 2011. All rights reserved.
World J Pediatr, Vol 7 No 2 . May 15, 2011 . www.wjpch.com
Key words: clinical trial; menthol; napkin dermatitis
Brief report
Background: The antibacterial, antifungal and probable anti-inflammatory effects of menthol were evaluated in the treatment of napkin dermatitis (ND).
Introduction
N
apkin dermatitis (ND) (commonly known as diaper rash or nappy rash) is a common disorder in neonates and infants, which is caused by activating factors including contacts, chemical stimulants and/or poor hygiene[1] as well as predisposing factors such as skin humidity, high skin pH[2] and infections.[3] A wide spectrum of gram positive (including Staphylococcus aureus) and gram negative bacteria can be isolated from the napkin area in the presence or absence of ND, and the role of bacterial infections is not well defined pathophysiologically.
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