Role of Potassium in Preventive Cardiovascular Medicine
Role of Potassium in Preventive Cardiovascular Medicine: Information related to this question has accumulated for nearly a hundred years, from work in cellular physiology, experimental studies in animals, clinical trials, and from population and epidemiol
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BASIC SCIENCE FOR THE CARDIOLOGIST 1.
B. Swynghedauw (ed.): Molecular Cardiology for the Cardiologist. Second Edition. 1998. ISBN: 0-7923-8323-0
2.
B. Levy, A. Tedgui (eds.): Biology of the Arterial Wall. 1999 ISBN 0-7923-8458-X
3.
M.R. Sanders, J.B. Kostis (eds): Molecular Cardiology in Clinical Practice. 1999. ISBN 0-7923-8602-7
4.
B. Ostadal, F. Kolar (eds.): Cardiac Ischemia: From Injury to Protection. 1999 ISBN 0-7923-8642-6
5.
H. Schunkert, G.A.J. Riegger (eds.): Apoptosis in Cardiac Biology. 1999. ISBN 0-7923-8648-5 A. Malliani, (ed.): Principles of Cardiovascular Neural Regulation in Health and Disease. ISBN 0-7923-7775-3
6. 7. 8.
P. Benlian : Genetics of Dyslipidemia. 200 1
ISBN 0-7923-7362-6
D. Young: Role of Potassium in Preventive Cardiovascular Medicine. 2001 ISBN 0-7923-7376-6
KLUWER ACADEMIC PUBLISHERS - DORDRECHT/BOSTON/LONDON
ROLE OF POTASSIUM IN PREVENTIVE CARDIOVASCULAR MEDICINE
by
David B. Young, Ph.D. University of Mississippi Medical Center, U.S.A.
KLUWER ACADEMIC PUBLISHERS Boston I Dordrecht I London
Distributors for North, Central and South America: Kluwer Academic Publishers 10 1 Philip Drive Assinippi Park Norwell, Massachusetts 02061 USA Distributors for all other countries: Kluwer Academic Publishers Group Distribution Centre Post Office Box 322 3300 AH Dordrecht, THE NETHERLANDS
Library of Congress Cataloging-in-Publication Data Young, David B. Role of potassium in preventive cardiovascular medicine / by David B. Young. p. ; cm. - (Basic Science for the cardiologist; 8) Includes bibliographical references and index. ISBN 0-7923-7376-6 (alk. paper) 1. Cardiovascular system--Pathophysiology. 2. Cardiovascular system--Diseases--Prevention. 3. Potassium--Physiological effect. I. Title. II. Series. [DNLM: I. Cardiovascular Diseases--prevention & control. 2. Cardiovascular Physiology. 3.Potassium--physiology.4. Potassium--therapeutic use. WG 120 Y69r 2001] RC669.9. Y68 2001 616.1 '05--dc21 200135419
Copyright © 2001 by Kluwer Academic Publishers All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Kluwer Academic Publishers, 101 Philip Drive, Assinippi Park, Norwell, Massachusetts 02061 Printed on acid-free paper.
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CONTENTS
FOREWORD
xiii
John H. Laragh, Jr., M.D.
1
INTRODUCTION
SECTION I:
2
1
POTASSIUM REGULATION
PHYSIOLOGY OF POTASSIUM REGULATION Potassium Transport Along the Nephron Regulation of Potassium Distribution
9
10 14
Hormonal and Non-Hormonal Factors that May Affect Potassium Excretion and Distribution
17
Long-Term Regulation of Potassium: Importance of Aldosterone and Extracellular Potassium Concentration Systems Analyses of Potassium Regulation
25 31
Summary
41
INTERACTIONS BETWEEN
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