Role of stress in the high cycle fatigue behavior of advanced 9Cr/CrMoV dissimilarly welded joint
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Title: Systematic review and network meta-analysis Medical therapies to prevent recurrence of post-operative Crohn’s disease.
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Ford1, 2*, Anthony O’Connor3* 1
Leeds Gastroenterology Institute, St. James’s University Hospital, Leeds, UK.
2
Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.
3
Department of Gastroenterology, Tallaght Hospital, Tallaght, Dublin 24, Ireland.
Dr Anthony O’Connor
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Correspondence:
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*Denotes joint last author
Address: Department of Gastroenterology, Tallaght University Hospital,
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Belgard Road, Dublin, D24NR0A, Ireland
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Email: [email protected] Telephone: +353 1 4144475
Author contributions: NEB, AOC & ACF conceived the study. NEB, BH & AOC extracted and
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analysed the data. All authors commented on drafts of the manuscript and approved the final version.
Disclosures: Nicholas E. Burr: Has received speaker fees and travel grants from Abbvie. Barry Hall: Has received speaker fees from Abbvie. John Hamlin: Has received speaker or advisory board fees from AbbVie, Merck Sharp Dome, Ferring, Janssen, Otsuka, Tillots, and Schering
Copyright © 2018 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected]
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Authors: Nicholas E. Burr1, 2, Barry Hall1, P. John Hamlin1, Christian P. Selinger1, Alexander C.
Manuscript Doi: 10.1093/ecco-jcc/jjy216 Plough. Christian P Selinger: Has received speaker or advisory board fees from Warner Chilcott, AbbVie, Dr FALK Pharma, Janssen, Merck Sharp Dome, and Takeda. Alexander C.
Aminosalicylic acid
CI
confidence interval
CD
Crohn’s disease
GI
gastrointestinal
MeSH
medical subject heading
RCT
randomised controlled trial
RR
relative risk
Ac c
ep
TNF
d
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an
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ASA
te
Abbreviations:
tumour necrosis factor
Downloaded from https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjy216/5250061 by INSEAD user on 18 December 2018
Ford: Has received speaker fees from Merck Sharp Dome & Shire. Anthony O’Connor: None.
Manuscript Doi: 10.1093/ecco-jcc/jjy216
Abstract Background and Aims
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of individuals post-operatively. The efficacy of several drugs to prevent post-operative recurrence has been studied in previous meta-analyses, but a number of randomised controlled trials (RCTs) have recently been published. We therefore performed an updated systematic review and network meta-analysis to investigate this issue.
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Methods
We performed a comprehensive literature search through to July 2018 to identify RCTs
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investigating the endoscopic and clinical recurrence of CD at 12 months post-operatively. We performed a random-effects network meta-analysis to produce a pooled relative risk (RR) with
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d
95% confidence intervals (CIs). We ranked the treatments according to their P
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