Rosacea Treatment: Review and Update
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REVIEW
Rosacea Treatment: Review and Update Hanlin Zhang . Keyun Tang . Yuchen Wang . Rouyu Fang . Qiuning Sun
Received: August 21, 2020 Ó The Author(s) 2020
ABSTRACT Key Summary Points Rosacea is a chronic and inflammatory skin disease characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. In 2017, a phenotype-based approach for diagnosis and classification was recommended. With the update of the diagnosis and classification of rosacea, treatment options for patients with rosacea have attracted the attention of dermatologists. Here, we summarize the latest advances in rosacea treatment, including skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosacea, treatments for systemic comorbidities, and combination therapies. The impact of the phenotype-based approach on rosacea treatment and future directions are also discussed.
Keywords: Oral therapies; Rosacea; Systemic comorbidities; Treatment; Topical therapies H. Zhang K. Tang Y. Wang R. Fang Q. Sun (&) Department of Dermatology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China e-mail: [email protected]
Rosacea is a chronic and inflammatory skin disease, characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. With the update of diagnosis and classification of rosacea in 2017, treatment options for rosacea patients also attracted the attention of dermatologists. The latest advances in rosacea treatment include skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosacea, treatments for systemic comorbidities, and combination therapies. This review may act as a supplement of recent rosacea treatment guidelines and expert consensus. Large-scale clinical research based on the phenotype approach is highly warranted in the future.
Dermatol Ther (Heidelb)
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INTRODUCTION Rosacea is a chronic and inflammatory disease with a series of facial skin manifestations, including flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes [1–4]. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea [5]. The pathogenesis and pathophysiology of rosacea are not fully understood [6–8], but immune dysfunction, Demodex infection, and exposure to ultraviolet radiation are considered to be contributing factors [2]. In
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