rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient
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COVID-19
rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient Özkan Görgülü 1
&
Murat Duyan 2
Accepted: 13 October 2020 # Springer Nature Switzerland AG 2020
Abstract In this study, we aimed to present a geriatric patient with the diagnosis of COVID-19 and with contradictory results in rRT-PCR examinations in short time intervals. A 69-year-old male patient was admitted to the emergency room on the 18th day of May 2020, with the complaints of fever, sweating, myalgia, dry cough that continued for 5 days, and the lack of taste that started on the day he applied to the emergency room. Comorbidity factors include diabetes mellitus, bronchial asthma, and hypertension. The patient has a history of 36 years of smoking 1.5 packs per day. High laboratory findings during hospitalization: monocytes, creatinine, CRP (C-reactive protein). In the thorax CT, in the parenchyma areas of both lungs, there are increases in attenuation with multilobe distributions (more visible at the level of the upper lobes) in the form of ground-glass opacities. May 19, 2020, was subjected to the rRT-PCR test, repeated twice on the 19th of May which also resulted in positive. Despite rRT-PCR tests, which were negative on 27th of May and positive on 28th of May, the patient, whose symptoms disappeared, and general condition improved, was discharged on June 1, 2020, with the recommendation for home isolation. In our case, unlike the incubation period only, we encountered a negative rRT-PCR result on the 8th day after diagnosis. Therefore, the COVID-19 pandemic control and filiation evaluation with the rRT-PCR test may produce false negative results. Keywords COVID-19 . SARS-CoV-2 . Geriatrics . Reverse transcriptase polymerase chain reaction . Tomography . Mass screening . False negative reactions
Introduction Coronavirus disease 2019 (COVID-19), also known as severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), is a new zoonotic infectious disease which was first reported to the World Health Organization on 31 December 2019, and which was declared as a pandemic by the WHO on March 11, 2020 [1]. COVID-19 continues to affect elderly adults disproportionately with severe patient losses, from severe hospitalization to This article is part of the Topical Collection on Covid-19 * Özkan Görgülü [email protected] Murat Duyan [email protected] 1
2
Department of Anesthesiology and Reanimation, Antalya Training and Research Hospital, Varlık Mh. Kazım Karabekir Cd, 07100 Antalya, Turkey Department of Emergency Medicine, Antalya Training and Research Hospital, Antalya, Turkey
increased risk of mortality [2]. Advances in various diagnostic approaches such as real-time polymerase chain reaction (rRT-PCR), chest radiography and computed tomography (CT) imaging, and other modern diagnostic methods for this infection have been emphasized as the major diagnostic tools [3]. rRT-PCR is the preferred method for measuring mRNA [4]. Definite diagnosis of COVID-19 is based on the viral isolation or positive result of polymerase chain rea
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