Safety and efficacy of hypertonic saline solution (5%) versus placebo in the treatment of postoperative corneal edema af
- PDF / 589,213 Bytes
- 12 Pages / 547.087 x 737.008 pts Page_size
- 104 Downloads / 196 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
ORIGINAL PAPER
Safety and efficacy of hypertonic saline solution (5%) versus placebo in the treatment of postoperative corneal edema after uneventful phacoemulsification: a randomized double-blind study Argyrios Tzamalis . Maria Dermenoudi . Asterios Diafas . Eirini Oustoglou . Artemis Matsou . Nikolaos Ziakas . Ioannis Tsinopoulos
Received: 1 October 2019 / Accepted: 18 April 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To evaluate safety and efficacy of hypertonic saline solution administration after uneventful cataract surgery. Design Prospective double-blind randomized study Methods In total, 183 eyes of 183 patients undergoing phacoemulsification were randomly allocated into two equal groups. Treatment group (TG) subjects received single-dose hypertonic (NaCl 5%) solution 4 times daily for 14 days, while placebo group (PG) received single dose of normal saline solution (0.9%) at the same frequency in addition to ordinary postoperative treatment. All patients underwent assessment of central corneal thickness (CCT), endothelial cell density (ECD), best-corrected visual acuity (BCVA), clinical staging of postoperative corneal edema and questionnaire regarding the procedure success and impact on patient’s life. Measurements were taken at baseline and 1, 4, 9 and 30 days following surgery. Results CCT increased by 134.67 ± 94.51 lm (25.1 ± 19.4%) on postoperative day 1, without any difference between study groups (p = 0.58). Corneal Asterios Diafas and Argyrios Tzamalis contributed equally to this work. A. Tzamalis (&) M. Dermenoudi A. Diafas E. Oustoglou A. Matsou N. Ziakas I. Tsinopoulos Department of Ophthalmology, Faculty of Medical School, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece e-mail: [email protected]
edema showed a significant recession in TG compared to PG on day 4, in terms of both pachymetry (10.73% vs 7.39%, p = 0.004), BCVA (BCVATG = 0.64 ± 0.24 [logMARTG = 0.25 ± 0.3], BCVAPG = 0.56 ± 0.23 [logMARPG = 0.33 ± 0.3], p = 0.04) and clinical staging (p = 0.02). Similar results were recorded on postoperative day 9 in subjects demonstrating marked corneal edema on the first postoperative day. Endothelial cell loss showed no statistically significant difference between study groups (p = 0.48). No adverse events were recorded in relation to treatment. More patients in the TG (92.4% vs 57.1% in the PG) reported a subjectively clear vision 1 week postoperatively (p = 0.04). Conclusion The use of 5% hypertonic saline solution is found to be a safe and effective adjunct in the management of postoperative corneal edema after uneventful phacoemulsification, achieving rapid corneal clearance and expediting a good visual outcome, especially in cases with marked postoperative edema. Keywords Postoperative corneal edema Cataract surgery Endothelial cell loss Hypertonic saline solution Postoperative treatment
Introduction Optimal vision depends on corneal transparency, which is ma
Data Loading...
