Sarcopenia as an independent predictor of the surgical outcomes of patients with inflammatory bowel disease: a meta-anal
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REVIEW ARTICLE
Sarcopenia as an independent predictor of the surgical outcomes of patients with inflammatory bowel disease: a meta‑analysis Adrienn Erős1,2 · Alexandra Soós1,3 · Péter Hegyi1,3,4,5 · Zsolt Szakács1,2 · Márton Benke6 · Ákos Szűcs6 · Petra Hartmann7 · Bálint Erőss1,2 · Patricia Sarlós1,2,5 Received: 31 May 2019 / Accepted: 8 September 2019 © The Author(s) 2019
Abstract Patients with inflammatory bowel disease (IBD) are at risk of sarcopenia, which is associated with poor clinical outcomes. We conducted this study to assess whether sarcopenia predicts the need for surgery and postoperative complications in patients with IBD. We performed a systematic search of four electronic databases, last updated in March, 2019. Data from studies comparing rates of surgery and postoperative complications in sarcopenic IBD patients versus non-sarcopenic IBD patients were pooled with the random-effects models. We calculated the odds ratios (OR) with a 95% confidence interval (CI). Ten studies with a collective total of 885 IBD patients were included in our meta-analysis. Although the analysis of raw data did not reveal significant differences between the two groups with respect to the rate of surgery and postoperative complications (OR = 1.826; 95% CI 0.913–3.654; p = 0.089 and OR = 3.265; 95% CI 0.575–18.557; p = 0.182, respectively), the analysis of adjusted data identified sarcopenia as an independent predictor for both of the undesirable outcomes (OR = 2.655; 95% CI 1.121–6.336; p = 0.027 and OR = 6.097; 95% CI 1.756–21.175; p = 0.004, respectively). Thus, early detection of sarcopenia in patients with IBD is important to prevent undesirable outcomes. Keywords Inflammatory bowel disease · Sarcopenia · Body composition · Surgery · Postoperative complications
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00595-019-01893-8) contains supplementary material, which is available to authorized users. * Patricia Sarlós [email protected] 1
Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, Pécs 7624, Hungary
2
Szentágothai Research Centre, University of Pécs, 20 Ifjúság Street, Pécs 7624, Hungary
3
Clinical Medicine Doctoral School, University of Szeged, 6 Korányi fasor, Szeged 6720, Hungary
4
Hungarian Academy of Sciences, University of Szeged Momentum Gastroenterology Multidisciplinary Research Group, 8‑10 Korányi fasor, Szeged 6720, Hungary
5
First Department of Medicine, Medical School, University of Pécs, 13 Ifjúság Street, Pécs 7624, Hungary
6
First Department of Surgery, Semmelweis University, 78 Üllői Street, Budapest 1082, Hungary
7
Institute of Surgical Research, University of Szeged, 1 Pulz Street, Szeged 6724, Hungary
Abbreviations ASMI Appendicular skeletal muscle index BMI Body mass index CD Crohn’s disease CI Confidence interval CRP C-reactive protein CT Computed tomography ECCO European Crohn’s and colitis organisation ESR Erythrocyte sedimentation rate EWGSOP European Wo
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