Screening for Cystic Fibrosis Using Liver Stiffness Measurements
Cystic fibrosis (CF) is the most common autosomal recessive metabolic disease with a current incidence of 1:3300–4800 in Germany and an annual increase of approximately 300 newborns. Hepatic involvement in CF, called cystic fibrosis liver disease (CFLD),
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Liver Elastography
Sebastian Mueller Editor
Liver Elastography Clinical Use and Interpretation
Editor Sebastian Mueller Department of Medicine and Center for Alcohol Research and Liver Diseases, Salem Medical Center University of Heidelberg Heidelberg Germany
ISBN 978-3-030-40541-0 ISBN 978-3-030-40542-7 (eBook) https://doi.org/10.1007/978-3-030-40542-7 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To my wife Ana and my children Julian and Ainhoa
Discovery consists of seeing what everybody has seen, and thinking what nobody has thought. Albert Szent-Györgyi
Preface to the First Edition
When asked by Springer Nature to publish a first-time book on liver stiffness and its clinical interpretation, I have been enthusiastic from the very beginning. Bedside measurement of liver stiffness by elastography, namely transient elastography, has been a breathless and inspiring journey since its first start in 2003. At this time, nobody could foresee that this rapid and noninvasive technique would not only drastically improve our abilities to screen patients for liver fibrosis, but also change and is still changing the daily management of patients with liver diseases. Without any exaggeration, it has become a silent but fascinating revolution in hepatology and can be considered essential for diagnosing and managing liver diseases today. Moreover, it has helped to rethink hitherto still poorly understood fundamentals of liver diseases, namely the pathology of cirrhosis and the role of pressure-related mechanisms. In this first comprehensive book entitled Liver Elastography: Its Clinical Use and Interpretation, the major advances are presented by tec
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