Self-assembly of stimuli-responsive block copolymers in aqueous solutions: an overview
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Self‑assembly of stimuli‑responsive block copolymers in aqueous solutions: an overview Mehul Khimani1 · Hiren Patel1 · Vijay Patel2 · Paresh Parekh3 · Rohit L. Vekariya4,5 Received: 11 November 2019 / Revised: 11 November 2019 / Accepted: 3 December 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract The review reports an aqueous solution behavior of commercially available and easy-to-use polymers, i.e., Pluronics®- and PNIPAM-based block copolymers. Both the polymers are stimuli responsive in nature. The present review covers the different aspects of aggregation behavior of Pluronics®- and PNIPAM-based block copolymeric micelles. Here, a comparison of physical properties such as EO–PO block, CP, CMC and CMT is made. Such physical parameters can be modulated with ease by the presence of external stimuli, viz. electrolytes, organic additives such as alcohols, phenols, amides and acids, different types of surfactants and water-soluble polymers, and also by modification of end groups of P luronics®. But in this review, our main focus is to study the addition of salts and non-electrolytes on the aggregation behavior of Pluronics®. With the help of above parameters, users can get idea about the stability, partition coefficient, solubilization capacity, etc. In analogy with Pluronics®, PNIPAM is also a thermo-responsive polymer with ~ 32 °C lower critical solution temperature (LCST). However, the LCST is independent of the degree of polymerization, i.e., molecular weight of homopolymer. However, the LCST can be tuned in the presence of external stimulus. PNIPAM-based di-block copolymers form various morphologies in different environments. An inverted morphology by
* Mehul Khimani [email protected] * Rohit L. Vekariya [email protected] 1
School of Science, P P Savani University, GETCO, NH‑8, Near Biltech, Village: Dhamdod, Kosamba, Dist.‑Surat, Gujarat 394125, India
2
Department of Chemistry, Jamanaben Narottambhai Motiram Patel Science College, Bharthana (Vesu), Surat, Gujarat 395017, India
3
Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, India
4
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
5
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
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Vol.:(0123456789)
Polymer Bulletin
double-hydrophilic-block copolymers is also possible. According to US and British Pharmacopoeia, some of the Pluronics® and PNIPAM are recognized as pharmaceutical excipients. Therefore, they have been extensively used for various pharmaceutical formulations. The other applications of these polymers are tissue engineering, bioseparation devices, active membranes, biosensors, rheological modifier, lithium batteries, etc. Graphic abstract
Keywords Block copolymers · Micellization · Stimuli-responsive polymers · Pluronics · Inverted morphology · Physicochemical techniques
Introduction Amphiphilic molecules contain two different parts within a same mol
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