Sensing Polymer/Paracetamol Interaction with an Independent Component Analysis-Based SERS-MIP Nanosensor
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Sensing Polymer/Paracetamol Interaction with an Independent Component Analysis-Based SERS-MIP Nanosensor N. Decorbie 1 & I. Tijunelyte 1 & S. Gam-Derouich 2 & J. Solard 3 & A. Lamouri 2 & P. Decorse 2 & N. Felidj 2 & C. Gauchotte-Lindsay 4 & E. Rinnert 5 & C. Mangeney 2,6 & N. Lidgi-Guigui 1 Received: 14 January 2020 / Accepted: 14 April 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this article, we propose a new strategy to build a sensor for easy handling and rapid analysis on-site. Our sensor is based on the combination of surface-enhanced Raman spectroscopy (SERS) and molecularly imprinted polymers (MIPs). SERS provides a strong sensitivity for the detection of trace molecules while MIPs offer a highly selective and specific recognition platform. The research presented here focuses on the detection of the interaction between a robust ultra-thin layer of MIPs and of paracetamol, the targeted molecule. This drug is an environmental emerging pollutant, i.e., a molecule whose presence and significance have not yet been elucidated, which gives rise to health and environmental concerns. The results are a combined analysis of the SERS spectra and a multivariate analysis. The former provides a clear demonstration of the evolution of the MIP-nanostructure interaction when the concentration of paracetamol increases. The statistical analysis produces the proof of the selectivity of the sensor. Keywords Sensor . SERS . Molecularly imprinted polymers . Emerging pollutant . Paracetamol . Independent component analysis
Introduction Molecularly imprinted polymers (MIPs) are highly selective materials made of robust artificial polymer matrices which ensure long-term stability and can compete with biological receptors like aptamers or antibody [1–3]. MIPs are obtained by the synthesis of crosslinked polymers in the presence of a * N. Lidgi-Guigui [email protected] 1
CSPBAT, (now LSPM), Sorbonne Paris Nord, 99 Av. JB Clément, 93430 Villetaneuse, France
2
Univ Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR CNRS 71086, 75013 Paris, France
3
Centrale de Proximité en Nanotechnologies de Paris Nord, Sorbonne Paris Nord, 99, Av. JB Clément, 93430 Villetaneuse, France
4
James Watt School of Engineering, University of Glasgow, Rankine Building, Oakfield Avenue, G12 8LT, Glasgow, UK
5
IFREMER, RDT-LDCM, Technopole Brest-Iroise, 29280 Plouzané, France
6
University of Paris, Lab Chim & Biochim Pharmacolog & Toxicol, UMR 8601, 75006 Paris, France
template molecule which, after extraction, leaves complementary cavities in the film. Rebinding the template by the MIPs is highly specific and selective as the artificial receptors are shaped by the template [4]. The main figure of merit of MIPs compare with their biological counterparts includes simple synthesis pathway and low cost, high stability to extreme chemical environment, and remarkable reusability. They are especially appropriate for the detection of small molecular compounds; this is probably why their occurrence
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