Sensitivity and specificity of choroidal thickness measurement by EDI-OCT for central serous chorioretinopathy diagnosis
- PDF / 683,131 Bytes
- 8 Pages / 547.087 x 737.008 pts Page_size
- 104 Downloads / 194 Views
(0123456789().,-volV) ( 01234567 89().,-volV)
ORIGINAL PAPER
Sensitivity and specificity of choroidal thickness measurement by EDI-OCT for central serous chorioretinopathy diagnosis Javier Ordun˜a-Azcona . Elia Pe´rez-Ferna´ndez . Ana M. Guadilla . Sofı´a De Manuel-Triantafilo . Laura Modamio . Pablo Gili
Received: 30 May 2020 / Accepted: 29 August 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To evaluate the utility of choroidal thickness (CT) measurement by enhanced depth imaging optical coherence tomography (EDI-OCT) for central serous chorioretinopathy (CSC) diagnosis. Methods Cross-sectional comparative study of 62 consecutive patients: 38 with acute CSC and 24 with macular subretinal fluid from differential diagnoses (DD). Subfoveolar choroidal thickness was measured using EDI 9-mm horizontal protocol. We evaluated sensitivity, specificity and intraclass correlation coefficient. Results Mean subfoveolar CT was greater in CSC group than in DD group (465.45 ± 115.42 lm vs. 347.54 ± 111.27 lm, p \ 0.001). The best threshold measure was 390 lm in patients younger than 50 years giving a sensitivity of 89.7% (CI 95%: 73.6–100%) and a specificity of 75% (CI 95%: 40.9–87.3%). For patients older than 50 years best J. Ordun˜a-Azcona (&) S. De Manuel-Triantafilo L. Modamio P. Gili Ophthalmology Unit, Hospital Universitario Fundacio´n Alcorco´n, Alcorco´n, Madrid, Spain e-mail: [email protected] J. Ordun˜a-Azcona A. M. Guadilla L. Modamio Ophthalmology Unit, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain E. Pe´rez-Ferna´ndez Research Unit, Hospital Universitario Fundacio´n Alcorco´n, Alcorco´n, Madrid, Spain
threshold measure was found at 400 lm giving a sensitivity of 45.5% (CI 95%: 21.3–72%) and a specificity of 80% (CI 95%: 58.4–91.9%). Intraclass correlation coefficient for CT measurement was 0.87 (CI 95%: 0.74–0.93). Conclusion CT measurement with EDI-OCT helps to differentiate CSC from other causes of macular subretinal fluid in patients younger than 50 years. Keywords Central serous chorioretinopathy Optical coherence tomography Sensitivity and specificity ROC curve Choroidal thickness
Introduction Central serous chorioretinopathy (CSC) is a disorder characterised by serous macular detachment and retinal pigment epithelial (RPE) changes. Although it is typically seen in young healthy men, it can also be seen in other age groups and can be misdiagnosed as other disorders that present with serous macular detachment that need prompt treatment. CSC pathogenesis has been attributed to choroid hyperpermeability [1]. Recently developed optical coherence tomography (OCT) modalities, such as enhanced depth imaging optical coherence tomography (EDI-OCT) or swept-source OCT, have allowed for choroid study due to their greater tissue penetrance
123
Int Ophthalmol
and higher definition. Previous publications reported greater choroidal thickness (CT) in eyes with CSC [2–6] and their fellows [4, 7–9] compared to normal controls, supporting the choroidal pathophysiology of this d
Data Loading...
