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Serum Ficolin-2 in Hospitalised Patients with Community-Acquired Pneumonia James D. Chalmers,1,6 Gilly B. Fleming,2 Julia Rutherford,2 Misao Matsushita,3 David C. Kilpatrick,4 and Adam T. Hill2,5

Abstract—Mannose binding lectin (MBL) and ficolins contribute to host defence through activation of the lectin pathway of complement. In this study, serum levels of ficolin-2 and MBL were determined in 276 patients with community-acquired pneumonia (CAP). MBL deficiency and ficolin-2 insufficiency were defined using previously validated cut-offs. No differences were observed in MBL or ficolin-2 between patients and controls. MBL-deficient patients (

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