Serum tenascin-C levels in atrium predict atrial structural remodeling processes in patients with atrial fibrillation
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Serum tenascin-C levels in atrium predict atrial structural remodeling processes in patients with atrial fibrillation Yuichiro Shiomi 1 & Miki Yokokawa 1 & Hiroyasu Uzui 1 & Kaori Hisazaki 1 & Tetsuji Morishita 1 & Kentaro Ishida 1 & Yoshitomo Fukuoka 1 & Kanae Hasegawa 1 & Hiroyuki Ikeda 1 & Naoto Tama 1 & Kenichi Kaseno 1 & Shinsuke Miyazaki 1 & Naoki Amaya 1 & Hiroshi Tada 1 Received: 25 November 2018 / Accepted: 19 November 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Background Fibro-inflammatory processes in the extracellular matrix are closely associated with progressive structural remodeling in atrial fibrillation (AF). Serum concentrations of tenascin-C (TNC), an extracellular matrix glycoprotein, and of highsensitivity C-reactive protein (CRP) might serve as a marker of remodeling and progressive inflammation of the aorta and in myocardial diseases. This study aimed to clarify relationships between TNC and CRP in patients with AF. Methods This study included 38 patients with AF and five controls without left ventricular dysfunction who underwent catheter ablation. Blood was collected immediately before ablation from the left atrium (LA), right atrium (RA), and femoral artery (FA), and left and right atrial pressure was measured. Levels of TNC in the LA (TNC-LA), RA (TNC-RA), and FA (TNC-FA) and high-sensitivity C-reactive protein (CRP) were measured. Atrial size was also determined by echocardiography. Results Levels of TNC corrected by atrial size were maximal in the LA, followed by the RA (3.69 ± 0.32 and 2.87 ± 0.38 ng/mL/ cm, respectively). Mean transverse diameter corrected by body surface area was larger and mean atrial pressure was greater in the LA than the RA. A relationship was found between CRP from the femoral vein and TNC-LA and TNC-RA, but not TNC-FA. None of TNC-LA, TNC-RA, or TNC-FA correlated with ANP or BNP in the femoral vein. Conclusions Intracardiac (atrial) TNC expression plays an important role in the development of remodeling processes in the atrium with AF. Tenascin-C from the LA and RA (but not TNC, ANP, and BNP from FA) might serve as novel markers of these processes. Keywords Atrial fibrillation . Atrial size . Tenascin-C . Atrial remodeling
1 Introduction Atrial fibrillation (AF) is a prevalent type of cardiac arrhythmia that can become complicated with thromboembolic events such as stroke and systemic embolism that result in s i g n i f i c a n t m o r b i d i t y a n d m o r t a l i t y. T h e r e f o r e , anticoagulation is an integral part of therapy for all patients with AF [1]. Structural remodeling of the left atrium is a mechanism for thrombus formation, similar to the activation of inflammatory states such as increased circulating concentrations of interleukin-6 or C-reactive protein [2].
Tenascin-C (TNC) is an extracellular matrix glycoprotein that is overexpressed during tissue remodeling, and its concentrations in peripheral veins might serve as markers for cardiac and vascular tissue remodeling in patients with acute myoca
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